B-Cell Scaffold Protein with Ankyrin Repeats 1, ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C.

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Small volumes of BANK1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2604023 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the B-Cell Scaffold Protein with Ankyrin Repeats 1 (BANK1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing BANK1. The ELISA analytical biochemical technique of the MBS2604023 kit is based on BANK1 antibody-BANK1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect BANK1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, BANK1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

73,674 Da

B-cell scaffold protein with ankyrin repeats 1

B-cell scaffold protein with ankyrin repeats

B-cell scaffold protein with ankyrin repeats

BANK1_HUMAN

The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

BANK1: Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2. Genetic variations in BANK1 influence susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4q24

Biological Process: B cell activation; negative regulation of B cell activation; negative regulation of protein kinase B signaling cascade; negative regulation of translational initiation; positive regulation of MAPKKK cascade

Disease: Systemic Lupus Erythematosus

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