Full Product Name
DOCK8 Antibody
Product Gene Name
anti-DOCK8 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8NF50
Other Notes
Small volumes of anti-DOCK8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for DOCK8. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001177387.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001190458.1
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UniProt Primary Accession #
Q8NF50
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UniProt Secondary Accession #
Q3MV16; Q5JPJ1; Q8TEP1; Q8WUY2; Q9BYJ5; Q9H1Q2; A2A350; A2BDF2; A4FU78; B7ZLP0; E9PH09[Other Products]
UniProt Related Accession #
Q8NF50[Other Products]
Molecular Weight
227,477 Da
NCBI Official Full Name
dedicator of cytokinesis protein 8 isoform 2
NCBI Official Synonym Full Names
dedicator of cytokinesis 8
NCBI Official Symbol
DOCK8 [Similar Products]
NCBI Official Synonym Symbols
MRD2; ZIR8; HEL-205
[Similar Products]
NCBI Protein Information
dedicator of cytokinesis protein 8
UniProt Protein Name
Dedicator of cytokinesis protein 8
Protein Family
Dedicator of cytokinesis protein
UniProt Gene Name
DOCK8 [Similar Products]
NCBI Summary for DOCK8
This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]
UniProt Comments for DOCK8
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (). Required for CD4+ T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780).
Research Articles on DOCK8
1. Recent advances in the understanding of DOCK8 function are summarized, paying particular attention to an emerging role as a signaling intermediate to promote immune responses to diverse external stimuli. [Review]
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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