Protein patched homolog 2, ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

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Small volumes of Ptch2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2888276 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Protein patched homolog 2 (Ptch2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Ptch2. The ELISA analytical biochemical technique of the MBS2888276 kit is based on Ptch2 antibody-Ptch2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Ptch2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Ptch2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

124,909 Da

patched 2

protein patched homolog 2

Protein patched homolog 2

PTC2  [Similar Products]

This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]

PTCH2: May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH). Belongs to the patched family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: integral component of membrane

Molecular Function: hedgehog receptor activity; smoothened binding

Biological Process: cell fate determination; epidermal cell fate specification; hair cycle; negative regulation of smoothened signaling pathway; positive regulation of epidermal cell differentiation; signal transduction; skin development

Disease: Basal Cell Carcinoma, Susceptibility To, 1; Basal Cell Nevus Syndrome; Medulloblastoma

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