CD35, Polyclonal Antibody

C3 binding protein; C3b/C4b receptor; C3BR; C4BR; CD35; CR1; KN

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

CD35 Antibody detects endogenous levels of total CD35

Affinity Chromatography

Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.

Small volumes of anti-CD35 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Mediates cellular binding of particles and immune complexes that have activated complement.

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

WB: 1:500-1:2000
IHC: 1:50-1:200
ICC/IF: 1:50-1:200

Western blot analysis of CD35 expression in TF1 cell lysate.

280kDa

complement C3b/C4b receptor 1 (Knops blood group)

complement receptor type 1

Complement receptor type 1

C3BR  [Similar Products]

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]

Mediates cellular binding of particles and immune complexes that have activated complement.(Microbial infection) Acts as a receptor for Epstein-Barr virus.

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