Full Product Name
Anti-Human CD35 Monoclonal Antibody (APC Conjugated)
Product Synonym Names
Complement receptor type 1; CR1; C3b/C4b receptor; CD35; CR1; C3BR
Product Gene Name
anti-CD35 antibody
[Similar Products]
Matching Pairs
Antibody: CD35 Clone #E11 (MBS2558410)
Isotype Control: IgG1, kappa Clone #MOPC-21 (MBS2557733)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P17927
Form/Format
PBS with 0.05% Proclin300, 1% BSA
Preparation and Storage
Store at 2-8 degree C and protect from prolonged exposure to light. Do not freeze.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CD35 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD35 antibody
CD35 is a type I single chain of glycoprotein, also known as C3b/C4b receptor, Complement Receptor type 1 or CR1. Four molecular weight allotypes (160kD, 190kD, 220kD, and 250kD) have been described. CD35 is expressed on granulocytes, monocytes, B cells, erythrocytes, and follicular dendritic cells, as well as subsets of NK and T cells. CD35 binds complement C3b, C4b, or iC3, and iC4, and plays important roles in both innate and adoptive immune response via mediating phagocytosis by granulocytes and monocytes. CD35 has also been reported to inhibit T-cell proliferation.
Applications Tested/Suitable for anti-CD35 antibody
Flow Cytometry (FC/FACS)
NCBI/Uniprot data below describe general gene information for CD35. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000642.3
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NCBI GenBank Nucleotide #
NP_000642.3
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UniProt Primary Accession #
P17927
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UniProt Related Accession #
P17927[Other Products]
NCBI Official Full Name
complement receptor type 1 isoform S
NCBI Official Synonym Full Names
complement C3b/C4b receptor 1 (Knops blood group)
NCBI Official Symbol
CR1 [Similar Products]
NCBI Official Synonym Symbols
KN; C3BR; C4BR; CD35
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NCBI Protein Information
complement receptor type 1
UniProt Protein Name
Complement receptor type 1
UniProt Synonym Protein Names
C3b/C4b receptor
UniProt Gene Name
CR1 [Similar Products]
UniProt Synonym Gene Names
C3BR [Similar Products]
UniProt Entry Name
CR1_HUMAN
NCBI Summary for CD35
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for CD35
CR1: Mediates cellular binding of particles and immune complexes that have activated complement. Belongs to the receptors of complement activation (RCA) family.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: cell surface; integral to plasma membrane; plasma membrane
Molecular Function: complement component C4b binding; complement component C3b receptor activity; complement component C4b receptor activity; complement component C3b binding
Biological Process: negative regulation of complement activation, alternative pathway; complement receptor mediated signaling pathway; negative regulation of complement activation, classical pathway; regulation of complement activation; innate immune response; complement activation, classical pathway
Disease: Knops Blood Group System; Malaria, Susceptibility To
Research Articles on CD35
1. The effects of the Knops polymorphisms on CR1 function remains unknown.
Precautions
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Disclaimer
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