Full Product Name
MGME1 Antibody, HRP conjugated
Product Synonym Names
Mitochondrial genome maintenance exonuclease 1UniRule annotation; MGME1
Product Gene Name
anti-MGME1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9BQP7
Purity/Purification
>95%, Protein G Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Immunogen
Recombinant human Mitochondrial genome maintenance exonuclease 1 protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-85434 / sc-85435
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-MGME1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MGME1 antibody
Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.
Applications Tested/Suitable for anti-MGME1 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for MGME1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001297267.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001310338.1
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UniProt Primary Accession #
Q9BQP7
[Other Products]
UniProt Secondary Accession #
Q96SW3; B2RDG5; D3DW29[Other Products]
UniProt Related Accession #
Q9BQP7[Other Products]
Molecular Weight
39,421 Da
NCBI Official Full Name
mitochondrial genome maintenance exonuclease 1 isoform 1
NCBI Official Synonym Full Names
mitochondrial genome maintenance exonuclease 1
NCBI Official Symbol
MGME1 [Similar Products]
NCBI Official Synonym Symbols
DDK1; MTDPS11; C20orf72; bA504H3.4
[Similar Products]
NCBI Protein Information
mitochondrial genome maintenance exonuclease 1
UniProt Protein Name
Mitochondrial genome maintenance exonuclease 1
Protein Family
Mitochondrial genome maintenance exonuclease
UniProt Gene Name
MGME1 [Similar Products]
UniProt Entry Name
MGME1_HUMAN
NCBI Summary for MGME1
The protein encoded by this gene is a nuclear-encoded mitochondrial protein necessary for the maintenance of mitochondrial genome synthesis. The encoded protein is a RecB-type exonuclease and primarily cleaves single-stranded DNA. Defects in this gene have been associated with mitochondrial DNA depletion syndrome-11. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]
UniProt Comments for MGME1
MGME1: an endo-/exonuclease involved in mitochondrial genome maintenance. Lacks detectable ribonuclease activity. Degrades DNA mainly in a 3'5' direction with a strong preference for single-stranded DNA. Requires free ends for its activity. Does not degrade circular substrates. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long- patch base excision repair. Overexpression decreases the levels of 7S DNA, suggesting an important role in 7S DNA regulation. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions (PEOAX), characterized by external ophthalmoplegia, emaciation and respiratory failure. Muscle biopsies show mtDNA depletion and multiple mtDNA deletions. A protein of the PD-(D/E)XK superfamily and MGME1 family. Belongs to the MGME1 family.
Protein type: Deoxyribonuclease; EC 3.1.-.-; Mitochondrial
Chromosomal Location of Human Ortholog: 20p11.23
Cellular Component: mitochondrion
Molecular Function: single-stranded DNA specific exodeoxyribonuclease activity
Biological Process: mitochondrial DNA repair; mitochondrial DNA replication; mitochondrial genome maintenance
Disease: Mitochondrial Dna Depletion Syndrome 11
Research Articles on MGME1
1. MGME1-mediated mtDNA processing is essential for faithful mitochondrial genome replication and might be required for intramolecular recombination of mtDNA.
Precautions
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Disclaimer
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