ATP-Sensitive Inward Rectifier Potassium Channel 10 (KCNJ10), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of KCNJ10 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9357706 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ATP-Sensitive Inward Rectifier Potassium Channel 10 (KCNJ10) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KCNJ10. The ELISA analytical biochemical technique of the MBS9357706 kit is based on KCNJ10 antibody-KCNJ10 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KCNJ10 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KCNJ10. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

42,508 Da

potassium voltage-gated channel subfamily J member 10

ATP-sensitive inward rectifier potassium channel 10

ATP-sensitive inward rectifier potassium channel 10

KCJ10_HUMAN

This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]

Kir4.1: May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Defects in KCNJ10 are the cause of seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SESAMES). A complex disorder characterized by generalized seizures with onset in infancy, delayed psychomotor development, ataxia, sensorineural hearing loss, hypokalemia, metabolic alkalosis, and hypomagnesemia. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.

Protein type: Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass; Channel, potassium

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: basolateral plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: ATP binding; ATP-activated inward rectifier potassium channel activity; protein binding

Biological Process: ***** walking behavior; glutamate uptake during transmission of nerve impulse; myelination in the central nervous system; potassium ion homeostasis; potassium ion import; potassium ion transport; regulation of long-term neuronal synaptic plasticity; regulation of resting membrane potential; synaptic transmission; visual perception

Disease: Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct; Pendred Syndrome; Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance

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