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Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g), Polyclonal Antibody

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产品名称: Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g), Polyclonal Antibody
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简单介绍

Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g), Polyclonal Antibody


Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g), Polyclonal Antibody  的详细介绍
Product Name

Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g), Polyclonal Antibody

Full Product Name

APC/CY7-Linked Polyclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g)

Product Synonym Names
ENaCg; ENaCgamma; PHA1; SCNEG; Sodium Channel, Nonvoltage-Gated 1, Alpha; Epithelial Na (+) channel subunit gamma; Nonvoltage-gated sodium channel 1 subunit gamma
Product Gene Name

anti-SCNN1g antibody

[Similar Products]
Matching Pairs
Unconjugated Antibody: Amiloride Sensitive Sodium Channel Subunit Gamma (MBS2027227)
APC-CY7 Conjugated Antibody: Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) (MBS2070948)
Matching Pairs
APC-CY7 Conjugated Antibody: Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) (MBS2070948)
Immunogen: Amiloride Sensitive Sodium Channel Subunit Gamma (MBS2030029)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
X87160 mRNA
3D Structure
ModBase 3D Structure for P51170
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Concentration
200ug/ml (lot specific)
Immunogen
SCNN1g (Met1~Val182)
Conjugation
APC-Cy7
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2027227
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-SCNN1g antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Applications Tested/Suitable for anti-SCNN1g antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
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NCBI/Uniprot data below describe general gene information for SCNN1g. It may not necessarily be applicable to this product.
NCBI GI #
42476333
NCBI GeneID
6340
NCBI Accession #
NP_001030.2 [Other Products]
NCBI GenBank Nucleotide #
NM_001039.3 [Other Products]
UniProt Primary Accession #
P51170 [Other Products]
UniProt Secondary Accession #
P78437; Q6PCC2; Q93023; Q93024; Q93025; Q93026; Q93027; Q96TD2[Other Products]
UniProt Related Accession #
P51170[Other Products]
Molecular Weight
74,270 Da
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NCBI Official Full Name
amiloride-sensitive sodium channel subunit gamma
NCBI Official Synonym Full Names
sodium channel epithelial 1 gamma subunit
NCBI Official Symbol
SCNN1G  [Similar Products]
NCBI Official Synonym Symbols
PHA1; BESC3; ENaCg; SCNEG; ENaCgamma
  [Similar Products]
NCBI Protein Information
amiloride-sensitive sodium channel subunit gamma
UniProt Protein Name
Amiloride-sensitive sodium channel subunit gamma
UniProt Synonym Protein Names
Epithelial Na(+) channel subunit gamma; ENaCG; Gamma-ENaC; Gamma-NaCH; Nonvoltage-gated sodium channel 1 subunit gamma; SCNEG
Protein Family
Amiloride-sensitive sodium channel
UniProt Gene Name
SCNN1G  [Similar Products]
UniProt Synonym Gene Names
ENaCG; Gamma-ENaC  [Similar Products]
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NCBI Summary for SCNN1g
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009]
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UniProt Comments for SCNN1g
ENaC-gamma: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Defects in SCNN1G are a cause of Liddle syndrome (LIDDS). It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel. Defects in SCNN1G are the cause of bronchiectasis with or without elevated sweat chloride type 3 (BESC3). A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily.

Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel

Chromosomal Location of Human Ortholog: 16p12.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: amiloride-sensitive sodium channel activity; ion channel activity; protein binding; sodium channel activity; WW domain binding

Biological Process: excretion; multicellular organismal water homeostasis; sodium ion homeostasis; sodium ion transport

Disease: Bronchiectasis With Or Without Elevated Sweat Chloride 3; Liddle Syndrome; Pseudohypoaldosteronism, Type I, Autosomal Recessive
Research Articles on SCNN1g
1. One nonsynonymous amino acid variants in SCNN1G in nonwhite Cystic fibrosis patients with non-diagnostic CFTR genotypes was identified.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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