Ack1-2, Polyclonal Antibody

Anti -Ack1-2 (Activated p21cdc42Hs Kinase)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 3; NC_000003.11 (195590236..195635880, complement). Location: 3q29

Polyclonal

IgY

Chicken

Recognizes human Ack1-2.

Affinity Purified
Purified by affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 

Small volumes of anti-TNK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Ack1-2 encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of

Antibodies; Abs to Protein Kinases

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:500

114,569 Da[Similar Products]

tyrosine kinase, non-receptor, 2

activated CDC42 kinase 1; ACK-1; OTTHUMP00000208563; OTTHUMP00000208564; OTTHUMP00000208565; OTTHUMP00000208566; activated p21cdc42Hs kinase; activated Cdc42-associated kinase 1; tyrosine kinase non-receptor protein 2

Activated CDC42 kinase 1

ACK1  [Similar Products]

ACK1_HUMAN

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq]

Ack: a tyrosine kinase that binds Cdc42 in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. May be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42 and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Amplification in primary tumors correlates with metastatic potential . Two differentially spliced isoforms have been described.

Protein type: Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Kinase, protein; EC 2.7.11.1; EC 2.7.10.2; TK group; Ack family

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: cytoplasmic vesicle membrane; clathrin-coated vesicle; dendrite; coated pit; extrinsic to internal side of plasma membrane; growth cone; adherens junction; membrane; cell soma; axon; cytoplasm; plasma membrane; nucleus; endosome

Molecular Function: protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; metal ion binding; WW domain binding; non-membrane spanning protein tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; ATP binding; GTPase inhibitor activity; epidermal growth factor receptor binding; hormone receptor binding

Biological Process: cell migration; positive regulation of peptidyl-tyrosine phosphorylation; cell surface receptor linked signal transduction; small GTPase mediated signal transduction; negative regulation of catalytic activity; innate immune response; endocytosis; cell differentiation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation

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