Full Product Name
GNE Antibody
Product Synonym Names
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-N-acetylglucosamine 2-epimerase; UDP-GlcNAc-2-epimerase; Uridine diphosphate-N-acetylglucosamine-2-epimeraseN-acetylmannosamine kinase; ManAc
Product Gene Name
anti-GNE antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y223
Species Reactivity
Human, Mouse, Rat
Specificity
GNE Antibody detects endogenous levels of total GNE
Purity/Purification
Immunogen affinity purified
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide
Preparation and Storage
Store at-20 degree C for 1 year
Other Notes
Small volumes of anti-GNE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GNE antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-GNE antibody
WB: 1:500~1:1000
IHC: 1:50~1:200
Western Blot (WB) of anti-GNE antibody
Western blot analysis of extracts from NIH/3T3 cells, using GNE antibody.
NCBI/Uniprot data below describe general gene information for GNE. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001121699.1
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NCBI GenBank Nucleotide #
NM_001128227.2
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UniProt Primary Accession #
Q9Y223
[Other Products]
UniProt Secondary Accession #
Q0VA94; A6PZH2; A6PZH3; A7UNU7; B2R6E1; B7Z372; B7Z428; D3DRP7; F5H499; H0YFA7[Other Products]
UniProt Related Accession #
Q9Y223[Other Products]
NCBI Official Full Name
bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 1
NCBI Official Synonym Full Names
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
NCBI Official Symbol
GNE [Similar Products]
NCBI Official Synonym Symbols
NM; DMRV; IBM2; Uae1; GLCNE
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NCBI Protein Information
bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
UniProt Protein Name
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
UniProt Synonym Protein Names
UDP-GlcNAc-2-epimerase/ManAc kinaseIncluding the following 2 domains:UDP-N-acetylglucosamine 2-epimerase (hydrolyzing) (EC:3.2.1.183)Alternative name(s):UDP-GlcNAc-2-epimerase; Uridine diphosphate-N-acetylglucosamine-2-epimerase
Protein Family
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
UniProt Gene Name
GNE [Similar Products]
UniProt Synonym Gene Names
GLCNE [Similar Products]
NCBI Summary for GNE
The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many
biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for GNE
Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.
Research Articles on GNE
1. This study showed thatsSeven patients out of 20 were found to have disease-causing mutations in genes associated with inclusion body myopathy genes allowing for inclusion body myopathy in the differential diagnosis or associated with unexpected diagnosis.
Precautions
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Disclaimer
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