Product Name
SAM domain and HD domain-containing protein 1 (SAMH1), Recombinant Protein
Full Product Name
Recombinant mouse SAM domain and HD domain-containing protein 1
Product Synonym Names
Interferon-gamma-inducible protein Mg11SAM domain and HD domain-containing protein 1
Product Gene Name
SAMH1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
395-626aa
3D Structure
ModBase 3D Structure for Q60710
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Form/Format
20mM Tris-HCl based buffer, pH8.0
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Other Notes
Small volumes of SAMH1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SAMH1 recombinant protein
Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling.
NCBI/Uniprot data below describe general gene information for SAMH1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001132992.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001139520.1
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UniProt Primary Accession #
Q60710
[Other Products]
UniProt Secondary Accession #
Q3U5X2; Q543A4; Q91VK8[Other Products]
UniProt Related Accession #
Q60710[Other Products]
NCBI Official Full Name
deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform 2
NCBI Official Synonym Full Names
SAM domain and HD domain, 1
NCBI Official Symbol
Samhd1 [Similar Products]
NCBI Official Synonym Symbols
Mg11; E330031J07Rik
[Similar Products]
NCBI Protein Information
deoxynucleoside triphosphate triphosphohydrolase SAMHD1
UniProt Protein Name
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
UniProt Synonym Protein Names
Interferon-gamma-inducible protein Mg11; SAM domain and HD domain-containing protein 1
UniProt Gene Name
Samhd1 [Similar Products]
UniProt Synonym Gene Names
Mg11; dNTPase [Similar Products]
UniProt Comments for SAMH1
SAMHD1: a protein induced by interferon gamma.
Protein type: EC 3.1.4.-
Chromosomal Location of Human Ortholog: 2|2 H1
Cellular Component: nucleoplasm; nucleus; plasma membrane
Molecular Function: dGTP binding; dGTPase activity; nucleic acid binding; ribonuclease activity; RNA binding; triphosphoric monoester hydrolase activity; zinc ion binding
Biological Process: dATP catabolic process; defense response to virus; dGTP catabolic process; protein homotetramerization; regulation of innate immune response
Research Articles on SAMH1
1. These data support a model in which SAMHD1 catalytic activity is regulated through tetramer stabilization by the carboxyl-terminal tail, phosphorylation destabilizing the complexes and inactivating the enzyme. ISF2 may serve to reduce the dNTP pool to very low levels as a means of restricting virus replication.
Precautions
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Disclaimer
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