B7H4, Monoclonal Antibody

Monoclonal B7H4 antibody; Anti-B7H4; BH4-7; B7H4;B7H4 antibody,BH4 7 ;BH4-7 antibody, B7S1 antibody; B7X antibody; B7-S1 antibody, BH4 7 antibody.

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1 kappa

H74

Mouse

Mouse

Liquid in PBS,pH 7.2, with 0.1% Gelatin and 0.09% Sodium Azide.

0.5 mg/mL (lot specific)

4°C only. DO NOT FREEZE.

Small volumes of anti-B7H4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Mouse monoclonal B7H4 antibody (biotin)

Immunology; Conjugated Monoclonal Antibodies

Suitable for use in Flow

A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Staining of non-transfected (left) and human B7-H4 transfected (right) 293T cells with Mouse IgG1 kappa Isotype Control (biotin) (open histogram) or 0.06 ug Anti-Human B7H4 (biotin) (filled histogram) followed by Streptavidin (PE). Total cells were used for analysis.

20,743 Da

V-set domain containing T cell activation inhibitor 1

V-set domain-containing T-cell activation inhibitor 1

V-set domain-containing T-cell activation inhibitor 1

B7-H4  [Similar Products]

VTCN1_HUMAN

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

VTCN1: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: integral to membrane; external side of plasma membrane

Molecular Function: receptor binding

Biological Process: response to protozoan; immune system process; positive regulation of T cell proliferation; negative regulation of T cell activation

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