Product Name
UBR1, cDNA Clone
Full Product Name
UBR1 cDNA Clone
Product Gene Name
UBR1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcggacg aggaggctgg aggtactgag aggatggaaa tcagcgcgga gttaccccag acccctcagc gtctggcatc ttggtgggat cagcaagttg atttttatac tgctttcttg catcatttgg cacaattggt gccagaaatt tactttgctg aaatggaccc agacttggaa aagcaggagg aaagtgtaca aatgtcaata ttcactccac tggaatggta cttatttgga gaagatccag atatttgctt agagaaattg aagcacagtg gagcatttca gctttgtggg agggttttca aaagtggaga gacaacctat tcttgcaggg attgtgcaat tgatccaaca tgtgtactct gtatggactg cttccaggac agtgttcata aaaatcatcg ttacaagatg catacttcta ctggaggagg gttctgtgac tgtggagaca cagaggcatg gaaaactggc cctttttgtg taaatcatga acctggaaga gcaggtacta taaaagagaa ttcacgctgt ccgttgaatg aagaggtaat tgtccaagcc aggaaaatat ttccttcagt gataaaatat gtcgtagaaa tgactatatg ggaagaggaa aaagaactgc ctcctgaact ccagataagg gagaaaaatg aaagatacta ttgtgtcctt ttcaatgatg aacaccattc atatgaccac gtcatataca gcctacaaag agctcttgac tgtgagctcg cagaggccca gttgcatacc actgccattg acaaagaggg tcgtcgggct gttaaagcgg gagcttatgc tgcttgccag gaagcaaagg aagatataaa gagtcattca gaaaatgtct ctcaacatcc acttcatgta gaagtattac actcagagat tatggctcat cagaaatttg ctttgcgtct tggttcctgg atgaacaaaa ttatgagcta ttcaagtgac tttaggcaga tcttttgcca agcatgcctt agagaagaac ctgactcgga gaatccctgt ctcataagca ggttaatgct ttgggatgca aagctttata aaggtgcccg taagatcctt catgaattga tcttcagcag tttttttatg gagatggaat acaaaaaact ctttgctatg gaatttgtga agtattataa acaactgcag aaagaatata tcagtgatga tcatgacaga agtatctcta taactgcact ttcagttcag atgtttactg ttcctactct ggctcgacat cttattgaag agcagaatgt tatctctgtc attactgaaa ctctgctaga agttttacct gagtacttgg acaggaacaa taaattcaac ttccagggtt atagccagga caaattggga agagtatatg cagtaatatg tgacctaaag tatatcctga tcagcaaacc cacaatatgg acagaaagat taagaatgca gttccttgaa ggttttcgat cttttttgaa gattcttacc tgtatgcagg gaatggaaga aatccgaaga caggttgggc aacacattga agtggatcct gattgggagg ctgccattgc tatacagatg caattgaaga atattttact catgttccaa gagtggtgtg cttgtgatga agaactctta cttgtggctt ataaagaatg tcacaaagct gtgatgaggt gcagtaccag tttcatatct agtagcaaga cagtagtaca atcgtgtgga catagtttgg aaacaaagtc ctacagagta tctgaggatc ttgtaagcat acatctgcca ctctctagga cccttgctgg tcttcatgta cgtttaagca ggctgggtgc tgtttcaaga ctgcatgaat ttgtgtcttt tgaggacttt caagtagagg tactagtgga atatccttta cgttgtctgg tgttggttgc ccaggttgtt gctgagatgt ggcgaagaaa tggactgtct cttattagcc aggtgtttta ttaccaagat gttaagtgca gagaagaaat gtatgataaa gatatcatca tgcttcagat tggtgcatct ttaatggatc ccaataagtt cttgttactg gtacttcaga ggtatgaact tgccgaggct tttaacaaga ccatatctac aaaagaccag gatttgatta aacaatataa tacactaata gaagaaatgc ttcaggtcct catctatatt gtgggtgagc gttatgtacc tggagtggga aatgtgacca aagaagaggt cacaatgaga gaaatcattc acttgctttg cattgaaccc atgccacaca gtgccattgc caaaaattta cctgagaatg aaaataatga aactggctta gagaatgtca taaacaaagt ggccacattt aagaaaccag gtgtatcagg ccatggagtt tatgaactaa aagatgaatc actgaaagac ttcaatatgt acttttatca ttactccaaa acccagcata gcaaggctga acatatgcag aagaaaagga gaaaacaaga aaacaaagat gaagcattgc cgccaccacc acctcctgaa ttctgccctg ctttcagcaa agtgattaac cttctcaact gtgatatcat gatgtacatt ctcaggaccg tatttgagcg ggcaatagac acagattcta acttgtggac cgaagggatg ctccaaatgg cttttcatat tctggcattg ggtttactag aagagaagca acagcttcaa aaagctcctg aagaagaagt aacatttgac ttttatcata aggcttcaag attgggaagt tcagccatga atatacaaat gcttttggaa aaactcaaag gaattcccca gttagaaggc cagaaggaca tgataacgtg gatacttcag atgtttgaca cagtgaagcg attaagagaa aaatcttgtt taattgtagc aaccacatca ggatcggaat ctattaagaa tgatgagatt actcatgata aagaaaaagc agaacgaaaa agaaaagctg aagctgctag gctacatcgc cagaagatca tggctcagat gtctgcctta cagaaaaact tcattgaaac tcataaactc atgtatgaca atacatcaga aatgcctggg aaagaagatt ccattatgga ggaagagagc accccagcag tcagtgacta ctctagaatt gctttgggtc ctaaacgggg tccatctgtt actgaaaagg aggtgctgac gtgcatcctt tgccaagaag aacaggaggt gaaaatagaa aataatgcca tggtattatc ggcctgtgtc cagaaatcta ctgccttaac ccagcacagg ggaaaaccca tagaactctc aggagaagcc ctagacccac ttttcatgga tccagacttg gcatatggaa cttatacagg aagctgtggt catgtaatgc acgcagtgtg ctggcagaag tattttgaag ctgtacagct gagctctcag cagcgcattc atgttgacct ttttgacttg gaaagtggag aatatctttg ccctctttgc aaatctctgt gcaatactgt gatccccatt attcctttgc aacctcaaaa gataaacagt gagaatgcag atgctcttgc tcaacttttg accctggcac ggtggataca gactgttctg gccagaatat caggttataa tataagacat gctaaaggag aaaacccaat tcctattttc tttaatcaag gaatgggaga ttctactttg gagttccatt ccatcctgag ttttggcgtt gagtcttcga ttaaatattc aaatagcatc aaggaaatgg ttattctctt tgccacaaca atttatagaa ttggattgaa agtgccacct gatgaaaggg atcctcgagt ccccatgctg acctggagca cctgcgcttt cactatccag gcaattgaaa atctattggg agatgaagga aaacctctgt ttggagcact tcaaaatagg cagcataatg gtctgaaagc attaatgcag tttgcagttg cacagaggat tacctgtcct caggtcctga tacagaaaca tctggttcgt cttctatcag ttgttcttcc taacataaaa tcagaagata caccatgcct tctgtctata gatctgtttc atgttttggt gggtgctgtg ttagcattcc catccttgta ttgggatgac cctgttgatc tgcagccttc ttcagttagt tcttcctata accaccttta tctcttccat ttgatcacca tggcacacat gcttcagata ctacttacag tagacacagg cctacccctt gctcaggttc aagaagacag tgaagaggct cattccgcat cttctttctt tgcagaaatt tctcaatata caagtggctc cattgggtgt gatattcctg gctggtattt gtgggtctca ctgaagaatg gcatcacccc ttatcttcgc tgtgctgcat tgtttttcca ctatttactt ggggtaactc cgcctgagga actgcatacc aattctgcag aaggagagta cagtgcactc tgtagctatc tatctttacc tacaaatttg ttcctgctct tccaggaata ttgggatact gtaaggccct tgctccagag gtggtgtgca gatcctgcct tactaaactg tttgaagcaa aaaaacaccg tggtcaggta ccctagaaaa agaaatagtt tgatagagct tcctgatgac tatagctgcc tcctgaatca agcttctcat ttcaggtgcc cacggtctgc agatgatgag cgaaagcatc ctgtcctctg ccttttctgt ggggctatac tatgttctca gaacatttgc tgccaggaaa ttgtgaacgg ggaagaggtt ggagcttgca tttttcacgc acttcactgt ggagccggag tctgcatttt cctaaaaatc agagaatgcc gagtggtcct ggttgaaggt aaagccagag gctgtgccta tccagctcct tacttggatg aatatggaga aacagaccct ggcctgaaga ggggcaaccc ccttcattta tctcgtgagc ggtatcggaa gctccatttg gtctggcaac aacactgcat tatagaagag attgctagga gccaagagac taatcagatg ttatttggat tcaactggca gttactgtga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of UBR1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for UBR1. It may not necessarily be applicable to this product.
NCBI Accession #
BC113505
[Other Products]
UniProt Secondary Accession #
O60708; O75492; Q14D45; Q68DN9; Q8IWY6; Q96JY4[Other Products]
UniProt Related Accession #
Q8IWV7[Other Products]
Molecular Weight
93,184 Da
NCBI Official Full Name
Homo sapiens ubiquitin protein ligase E3 component n-recognin 1, mRNA
NCBI Official Synonym Full Names
ubiquitin protein ligase E3 component n-recognin 1
NCBI Official Symbol
UBR1 [Similar Products]
NCBI Official Synonym Symbols
JBS
[Similar Products]
NCBI Protein Information
E3 ubiquitin-protein ligase UBR1
UniProt Protein Name
E3 ubiquitin-protein ligase UBR1
UniProt Synonym Protein Names
N-recognin-1; Ubiquitin-protein ligase E3-alpha-1; Ubiquitin-protein ligase E3-alpha-I
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
UBR1 [Similar Products]
UniProt Entry Name
UBR1_HUMAN
NCBI Summary for UBR1
The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]
UniProt Comments for UBR1
UBR1: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Defects in UBR1 are a cause of Johanson-Blizzard syndrome (JBS). This disorder includes congenital exocrine pancreatic insufficiency, multiple malformations such as nasal wing aplasia, and frequent mental retardation. Pancreas of individuals with JBS do not express UBR1 and show intrauterine- onset destructive pancreatitis. Belongs to the UBR1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligase; Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.-; EC 6.3.2.19
Chromosomal Location of Human Ortholog: 15q13
Cellular Component: cytoplasm; ubiquitin ligase complex
Biological Process: negative regulation of TOR signaling pathway
Disease: Johanson-blizzard Syndrome
Research Articles on UBR1
1. Reduced UBR1 expression affects MGMT turnover and DNA repair in the smokers lungs.
Precautions
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Disclaimer
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