chloride channel 7, ELISA Kit

Rat H (+) /Cl (-) exchange transporter 7 (CLCN7) ELISA kit; CLC-7; CLC7; FLJ26686; FLJ39644; FLJ46423; OPTA2; OPTB4; ; chloride channel 7

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of CLCN7 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9331722 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the chloride channel 7 (CLCN7) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CLCN7. The ELISA analytical biochemical technique of the MBS9331722 kit is based on CLCN7 antibody-CLCN7 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CLCN7 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CLCN7. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

88,731 Da

chloride channel, voltage-sensitive 7

H(+)/Cl(-) exchange transporter 7; H(+)/Cl(-) exchange transporter 7; chloride channel protein 7; chloride channel 7 alpha subunit

H(+)/Cl(-) exchange transporter 7

ClC-7  [Similar Products]

CLCN7_RAT

putative voltage-gated chloride channel; mutation in human and mouse homologs is associated with osteopetrosis and retinal degeneration [RGD, Feb 2006]

CLCN7: Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen. Defects in CLCN7 are the cause of osteopetrosis autosomal recessive type 4 (OPTB4); also known as infantile malignant osteopetrosis type 2. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or *****hood. Defects in CLCN7 are the cause of osteopetrosis autosomal dominant type 2 (OPTA2); also known as autosomal dominant Albers-Schonberg disease or marble disease autosomal dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or *****hood. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or *****hood. It is characterized by sclerosis, predominantly involving the spine, the pelvis and the skull base. Belongs to the chloride channel (TC 2.A.49) family. ClC-7/CLCN7 subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, ion channel; Channel, chloride; Transporter

Cellular Component: membrane; lysosomal membrane; integral to membrane; cytoplasmic vesicle

Molecular Function: voltage-gated chloride channel activity; ATP binding; antiporter activity

Biological Process: chloride transport; response to pH

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