Full Product Name
CLC-7 Polyclonal Antibody
Product Gene Name
anti-CLC-7 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P51798
Other Notes
Small volumes of anti-CLC-7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CLC-7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001107803.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001114331.2
[Other Products]
UniProt Primary Accession #
P51798
[Other Products]
UniProt Secondary Accession #
Q9NYX5; A6NEJ7; A8K5T9; A8K7X1; B3KPN3; E9PDB9[Other Products]
UniProt Related Accession #
P51798[Other Products]
Molecular Weight
86,026 Da
NCBI Official Full Name
H(+)/Cl(-) exchange transporter 7 isoform b
NCBI Official Synonym Full Names
chloride voltage-gated channel 7
NCBI Official Symbol
CLCN7 [Similar Products]
NCBI Official Synonym Symbols
CLC7; CLC-7; OPTA2; OPTB4; PPP1R63
[Similar Products]
NCBI Protein Information
H(+)/Cl(-) exchange transporter 7
UniProt Protein Name
H(+)/Cl(-) exchange transporter 7
UniProt Synonym Protein Names
Chloride channel 7 alpha subunit; Chloride channel protein 7; ClC-7
UniProt Gene Name
CLCN7 [Similar Products]
UniProt Synonym Gene Names
ClC-7 [Similar Products]
NCBI Summary for CLC-7
The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or *****hood. [provided by RefSeq, Jul 2008]
UniProt Comments for CLC-7
Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen.
Research Articles on CLC-7
1. In this study, whole exome sequencing (WES) was successfully used in six patients with malignant infantile osteopetrosis (MIOP) and identified mutations in four MIOP-related genes (CLCN7, TCIRG1, SNX10, and TNFRSF11A).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
