Full Product Name
Anti-Human CD18 Monoclonal Antibody (PE Conjugated)
Product Synonym Names
Integrin beta-2; Itgb2; Cell surface adhesion glycoproteins LFA-1/CR3/p150+95 subunit beta; Complement receptor C3 subunit beta; CD18
Product Gene Name
anti-CD18 antibody
[Similar Products]
Matching Pairs
Antibody: CD18 Clone #TS1/18.1.2.11 (MBS2556483)
Isotype Control: IgG1, kappa Clone #MOPC-21 (MBS2557732)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P05107
Clone Number
TS1/18.1.2.11
Form/Format
Liquid; PBS with 0.05% Proclin300, 1% BSA
Preparation and Storage
Store at 2-8 degree C and protect from prolonged exposure to light. Do not freeze.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CD18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD18 antibody
CD18 is a 90-95 kD type I transmembrane protein also known as integrin beta2 subunit, LFA-1 beta subunit, and beta2 integrin. CD18 non-covalently associates with CD11a, CD11b or CD11c. CD18 is expressed on all leukocytes. CD18 and associated alpha chains function in adhesion and signaling in hematopoietic cells.
Applications Tested/Suitable for anti-CD18 antibody
Flow Cytometry (FC/FACS)
Flow Cytometry (FC/FACS) of anti-CD18 antibody
Human peripheral blood lymphocytes are stained with Anti-Human CD18 Monoclonal Antibody(PE Conjugated)(filled gray histogram). Unstained lymphocytes (empty black histogram) are used as control.
NCBI/Uniprot data below describe general gene information for CD18. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000202.3
[Other Products]
NCBI GenBank Nucleotide #
NM_000211.5
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UniProt Primary Accession #
P05107
[Other Products]
UniProt Secondary Accession #
Q16418; Q53HS5; Q9UD72; B3KTS8; D3DSM1[Other Products]
UniProt Related Accession #
P05107[Other Products]
Molecular Weight
84,782 Da
NCBI Official Full Name
integrin beta-2 isoform 1
NCBI Official Synonym Full Names
integrin subunit beta 2
NCBI Official Symbol
ITGB2 [Similar Products]
NCBI Official Synonym Symbols
LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
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NCBI Protein Information
integrin beta-2
UniProt Protein Name
Integrin beta-2
UniProt Synonym Protein Names
Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD_antigen: CD18
Protein Family
CD180 antigen
UniProt Gene Name
ITGB2 [Similar Products]
UniProt Synonym Gene Names
CD18; MFI7 [Similar Products]
NCBI Summary for CD18
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Comments for CD18
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407).
Product References and Citations for anti-CD18 antibody
1. Hogg N, et al. 1999. J. Clin. Invest. 103:97. 2. Anderson DC, et al. 1987. Annu. Rev. Med. 38:175. 3. Springer TA. 1994. Cell 76:301.
Research Articles on CD18
1. CD18-mediated adhesion of extracellular vesicles is a prerequisite for their proinflammatory activity.
Precautions
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Disclaimer
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