SAMHD1, Monoclonal Antibody

Monoclonal SAMHD1; Anti-SAMHD1; Sam Domain And Hd Domain 1; DCIP; HDDC1; MOP-5; SBBI88; SAMHD1; SAMHD 1; SAMHD-1

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG2b

3F5

Mouse

SAMHD1 antibody was purified by affinity chromatography.

Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.

500 ug-1 mg/ml (lot specific)

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Small volumes of anti-SAMHD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Mouse monoclonal SAMHD1 antibody

Protein Modification & Stress Response

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)

FC: 1:100
IF: 1:100
IHC: 1:150
WB: 1:200-500

Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant SAMHD1 protein (Right) or empty vector (Left) detected with SAMHD1 antibody

Immunohistochemical analysis of SAMHD1 protein in paraffin embedded Human pancreas tissue using SAMHD1 antibody

Immunofluorescent staining of COS7 cells transiently transfected with recombinant SAMHD1 protein using SAMHD1 antibody

68,122 Da

SAM domain and HD domain 1

deoxynucleoside triphosphate triphosphohydrolase SAMHD1

Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

MOP5; dNTPase; DCIP; MOP-5  [Similar Products]

SAMH1_HUMAN

This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010]

SAMHD1: a protein induced by interferon gamma.

Protein type: EC 3.1.4.-

Chromosomal Location of Human Ortholog: 20pter-q12

Cellular Component: nucleoplasm; plasma membrane; intracellular; nucleus

Molecular Function: protein binding; nucleic acid binding; dGTPase activity; zinc ion binding; RNA binding; dGTP binding

Biological Process: dGTP catabolic process; dATP catabolic process; cytokine and chemokine mediated signaling pathway; immune response; defense response to virus; regulation of innate immune response; protein homotetramerization

Disease: Chilblain Lupus 2; Aicardi-goutieres Syndrome 5

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