Endothelin 3, Peptide

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 20; NC_000020.10 (57875499..57901047). Location: 20q13.2-q13.3

Synthetic peptide

Highly Purified
~95%. Purified by HPLC.

Supplied as a lyophilized powder.

Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
 

Small volumes of EDN3 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Endothelins (ET) show potent constrictor activity in vascular and non-vascular smooth muscle. This family of 21-amino acid peptides exists in at least three isoforms, ET-1, ET-2, and ET-3, and is produced in endothelial and epithelial cells. ET's can mediate biological effects in cells and tissues, and have been shown to bind to an ET receptor in the lung, kidney, heart and liver.

Molecular Biology; MB-Peptides

25,454 Da[Similar Products]

endothelin 3

endothelin-3; preproendothelin-3

Endothelin-3

ET-3; PPET3  [Similar Products]

EDN3_HUMAN

The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Function: Endothelins are endothelium-derived vasoconstrictor peptides.

Subcellular location: Secreted.

Tissue specificity: Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells. Ref.9

Involvement in disease: Hirschsprung disease 4 (HSCR4) [MIM:613712]: A disorder of neural crest development characterized by absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting, abdominal distention and failure to pass stool, to chronic constipation in the older child.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.14Congenital central hypoventilation syndrome (CCHS) [MIM:209880]: Rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13Waardenburg syndrome 4B (WS4B) [MIM:613265]: A disorder characterized by the association of Waardenburg features (depigmentation and deafness) with the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12 Ref.15 Ref.16

Sequence similarities: Belongs to the endothelin/sarafotoxin family.

Sequence caution: The sequence AAR16083.1 differs from that shown. Reason: Erroneous gene model prediction.

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