Product Name
SECISBP2, Polyclonal Antibody
Full Product Name
SECISBP2 (Selenocysteine Insertion Sequence-binding Protein 2, SECIS-binding Protein 2, SBP2)
Product Synonym Names
Anti -SECISBP2 (Selenocysteine Insertion Sequence-binding Protein 2, SECIS-binding Protein 2, SBP2)
Product Gene Name
anti-SECISBP2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MASEGPREPE SEGIKLSADV KPFVPRFAGL NVAWLESSEA CVFPSSAATY YPFVQEPPVT EQKIYTEDMA FGASTFPPQY LSSEITLHPY AYSPYTLDST QNVYSVPGSQ YLYNQPSCYR GFQTVKHRNE NTCPLPQEMK ALFKKKTYDE KKTYDQQKFD SERADGTISS EIKSARGSHH LSIYAENSLK SDGYHKRTDR KSRIIAKNVS TSKPEFEFTT LDFPELQGAE NNMSEIQKQP KWGPVHSVST DISLLREVVK PAAVLSKGEI VVKNNPNESV TANAATNSPS CTRELSWTPM GYVVRQTLST ELSAAPKNVT SMINLKTIAS SADPKNVSIP SSEALSSDPS YNKEKHIIHP TQKSKASQGS DLEQNEASRK NKKKKEKSTS KYEVLTVQEP PRIEDAEEFP NLAVASERRD RIETPKFQSK QQPQDNFKNN VKKSQLPVQL DLGGMLTALE KKQHSQHAKQ SSKPVVVSVG AVPVLSKECA SGERGRRMSQ MKTPHNPLDS SAPLMKKGKQ REIPKAKKPT SLKKIILKER QERKQRLQEN AVGPAFTSDD TQDGESGGDD QFPEQAELSG PEGMDELIST PSVEDKSEEP PGTELQRDTE ASHLAPNHTT FPKIHSRRFR DYCSQMLSKE VDACVTDLLK ELVRFQDRMY QKDPVKAKTK RRLVLGLREV LKHLKLKKLK CVIISPNCEK IQSKGGLDDT LHTIIDYACE QNIPFVFALN RKALGRSLNK AVPVSVVGIF SYDGAQDQFH KMVELTVAAR QAYKTMLENV QQELVGEPRP QAPPSLPTQG PSCPAEDGPP ALKEKEEPHY IEIWKKHLEA YSGCTLELEE SLEASTSQMM NLNL
Chromosome Location
Chromosome: 9; NC_000009.11 (91933394..91974561). Location: 9q22.2
3D Structure
ModBase 3D Structure for Q96T21
Specificity
Recognizes human SECISBP2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Immunogen
Full length human SECISBP2, aa1-854 (AAH36109.1).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-SECISBP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-SECISBP2 antibody
Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-SECISBP2 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-SECISBP2 antibody
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml
NCBI/Uniprot data below describe general gene information for SECISBP2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_076982.3
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NCBI GenBank Nucleotide #
NM_024077.4
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UniProt Primary Accession #
Q96T21
[Other Products]
UniProt Secondary Accession #
Q5HYY1; Q8IYC0; Q9H0A1[Other Products]
UniProt Related Accession #
Q96T21[Other Products]
Molecular Weight
95,462 Da[Similar Products]
NCBI Official Full Name
selenocysteine insertion sequence-binding protein 2 isoform 1
NCBI Official Synonym Full Names
SECIS binding protein 2
NCBI Official Symbol
SECISBP2 [Similar Products]
NCBI Official Synonym Symbols
SBP2
[Similar Products]
NCBI Protein Information
selenocysteine insertion sequence-binding protein 2
UniProt Protein Name
Selenocysteine insertion sequence-binding protein 2
Protein Family
Selenocysteine insertion sequence-binding protein
UniProt Gene Name
SECISBP2 [Similar Products]
UniProt Synonym Gene Names
SBP2; SECIS-binding protein 2 [Similar Products]
UniProt Entry Name
SEBP2_HUMAN
NCBI Summary for SECISBP2
The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
UniProt Comments for SECISBP2
SECISBP2: Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB. Defects in SECISBP2 are a cause of abnormal thyroid hormone metabolism (ATHYHM). This phenotype is associated with a reduction in type II iodothyronine deiodinase activity. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Translation
Chromosomal Location of Human Ortholog: 9q22.2
Cellular Component: nucleoplasm; mitochondrion; ribonucleoprotein complex
Molecular Function: ribonucleoprotein binding; mRNA 3'-UTR binding
Biological Process: selenocysteine incorporation
Disease: Thyroid Hormone Metabolism, Abnormal
Research Articles on SECISBP2
1. The patient showed typical symptoms of SBP2 deficiency, and novel compound heterozygous mutations were identified in SBP2 (p.M515fsX563/p.Q79X).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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