Product Name
Chymotrypsin (CTRC), Monoclonal Antibody
Full Product Name
Chymotrypsin Monoclonal Antibody
Product Synonym Names
Anti-Chymotrypsin; Chymotrypsin
Product Gene Name
anti-CTRC antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q99895
Specificity
Anti-Chymotrypsin [Human pancreatic chymotrypsin (4 clones). LP]
These antibodies do not cross-react with human pancreatic trypsin.
Form/Format
1 ml ascites or 1 mg Protein G-purified antibody in PBS, pH 7.4
Antigen
Purified human pancreatic chymotrypsin.
Activity
Ig mg/ml* :16.9
ELISA Titer**:1:204,800
(Note: * Determined by radial immunodiffusion for several lots of ascites.
**ELISA is an indirect assay against human pancreatic chymotrypsin on the solid phase. Titers represent endpoint dilutions that achieve absorbance values >= 0.1)
Preservatives
None. Available on request
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of anti-CTRC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CTRC antibody
Enzyme and Enzyme Inhibitor Antibodies
Applications Tested/Suitable for anti-CTRC antibody
Western Blot, Immunoassay
Application Notes for anti-CTRC antibody
These antibodies may be used in immunoassays and Western Blotting to identify chymotrypsin. Other applications are under investigation
NCBI/Uniprot data below describe general gene information for CTRC. It may not necessarily be applicable to this product.
NCBI Accession #
CAA74031.1
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UniProt Primary Accession #
Q99895
[Other Products]
UniProt Related Accession #
Q68DR9; Q99895[Other Products]
Molecular Weight
7,728 Da[Similar Products]
NCBI Official Full Name
chymotrypsin
NCBI Official Synonym Full Names
chymotrypsin C (caldecrin)
NCBI Official Symbol
CTRC [Similar Products]
NCBI Official Synonym Symbols
CLCR; ELA4; CTRC
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NCBI Protein Information
chymotrypsin C; caldecrin; elastase 4; elastase IV; serum calcium decreasing factor
UniProt Protein Name
Putative uncharacterized protein DKFZp779K0837
Protein Family
Chymotrypsin
UniProt Gene Name
DKFZp779K0837 [Similar Products]
UniProt Synonym Gene Names
CTRC [Similar Products]
UniProt Entry Name
Q68DR9_HUMAN
NCBI Summary for CTRC
This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq]
UniProt Comments for CTRC
CTRC: Has chymotrypsin-type protease activity and hypocalcemic activity. Genetic variations in CTRC can predispose to chronic pancreatitis by diminishing its protective trypsin-degrading activity. Belongs to the peptidase S1 family. Elastase subfamily.
Protein type: Protease; EC 3.4.21.2
Chromosomal Location of Human Ortholog: 1p36.21
Molecular Function: peptidase activity; serine-type endopeptidase activity
Biological Process: proteolysis
Disease: Pancreatitis, Hereditary
Research Articles on CTRC
1. Novel CTRC gene variations and single nucleotide polymorphisms are associated with chymotrypsin C in a Chinese population.
2. Observational study of gene-disease association. (HuGE Navigator)
3. Study analyzed the gene encoding the trypsin-degrading enzyme chymotrypsin C in German subjects with idiopathic or hereditary chronic pancreatitis; 2 alterations in this gene were significantly overrepresented in the pancreatitis group.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
