Full Product Name
Phospho-4E-BP1 (Thr36) Antibody
Product Gene Name
anti-4E-BP1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13541
Species Reactivity
Human, Mouse, Rat
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-4E-BP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-4E-BP1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for 4E-BP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004086.1
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NCBI GenBank Nucleotide #
NM_004095.3
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UniProt Primary Accession #
Q13541
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UniProt Secondary Accession #
Q6IBN3; B2R502; D3DSW8[Other Products]
UniProt Related Accession #
Q13541[Other Products]
Molecular Weight
12,580 Da
NCBI Official Full Name
eukaryotic translation initiation factor 4E-binding protein 1
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 4E binding protein 1
NCBI Official Symbol
EIF4EBP1 [Similar Products]
NCBI Official Synonym Symbols
BP-1; 4EBP1; 4E-BP1; PHAS-I
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NCBI Protein Information
eukaryotic translation initiation factor 4E-binding protein 1
UniProt Protein Name
Eukaryotic translation initiation factor 4E-binding protein 1
UniProt Synonym Protein Names
Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
UniProt Gene Name
EIF4EBP1 [Similar Products]
UniProt Synonym Gene Names
4E-BP1; eIF4E-binding protein 1; PHAS-I [Similar Products]
NCBI Summary for 4E-BP1
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
UniProt Comments for 4E-BP1
4E-BP1: binds to eIF4E, preventing its assembly into the EIF4F complex and inhibiting cap-dependent translation. Phosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the PI3 kinase pathway.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 8p11.23
Cellular Component: cytoplasm; cytosol; nucleoplasm
Molecular Function: eukaryotic initiation factor 4E binding; protein binding; translation repressor activity
Biological Process: G1/S transition of mitotic cell cycle; negative regulation of translational initiation; positive regulation of mitotic cell cycle; TOR signaling pathway
Research Articles on 4E-BP1
1. Increased expression of miR-125a is associated with invasion and migration in ovarian cancer.
Precautions
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Disclaimer
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