centrosomal protein 57kDa, ELISA Kit

Human Centrosomal protein of 57 kDa (CEP57) ELISA kit; KIAA0092; PIG8; TSP57; proliferation-inducing protein 8; translokin; centrosomal protein 57kDa

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of CEP57 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9328458 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the centrosomal protein 57kDa (CEP57) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CEP57. The ELISA analytical biochemical technique of the MBS9328458 kit is based on CEP57 antibody-CEP57 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CEP57 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CEP57. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

57,089 Da

centrosomal protein 57kDa

centrosomal protein of 57 kDa; translokin; FGF2-interacting protein; testis-specific protein 57; proliferation-inducing protein 8

Centrosomal protein of 57 kDa

KIAA0092; TSP57; Cep57  [Similar Products]

CEP57_HUMAN

This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

CEP57: Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring- like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2. Defects in CEP57 are the cause of mosaic variegated aneuploidy syndrome type 2 (MVA2). MVA2 is a severe developmental disorder characterized by mosaic aneuploidies, predominantly trisomies and monosomies, involving multiple different chromosomes and tissues. Affected individuals typically present with severe intrauterine growth retardation and microcephaly. Eye anomalies, mild dysmorphism, variable developmental delay, and a broad spectrum of additional congenital abnormalities and medical conditions may also occur. The risk of malignancy is high, with rhabdomyosarcoma, Wilms tumor and leukemia reported in several cases. Belongs to the translokin family. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 11q21

Cellular Component: microtubule cytoskeleton; nucleoplasm; Golgi apparatus; microtubule; centrosome; cytoplasm; cytosol; nucleus

Molecular Function: gamma-tubulin binding; protein binding; fibroblast growth factor binding; protein homodimerization activity; microtubule binding

Biological Process: fibroblast growth factor receptor signaling pathway; protein import into nucleus, translocation; organelle organization and biogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; protein homooligomerization; spermatid development

Disease: Mosaic Variegated Aneuploidy Syndrome 2

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