homeobox A2, ELISA Kit

Human Homeobox protein Hox-A2 (HOXA2) ELISA kit; HOX1K; homeobox protein HOX-A2; homeobox A2

For Research Use Only. Not for use in diagnostic procedures.

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of HOXA2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9326955 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the homeobox A2 (HOXA2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HOXA2. The ELISA analytical biochemical technique of the MBS9326955 kit is based on HOXA2 antibody-HOXA2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HOXA2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HOXA2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of HOXA2 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

41,002 Da

homeobox A2

homeobox protein Hox-A2; homeobox protein Hox-1K

Homeobox protein Hox-A2

HOX1K  [Similar Products]

HXA2_HUMAN

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. [provided by RefSeq, Jul 2008]

HOXA2: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXA2 are a cause of microtia hearing impairment and cleft palate (MHICP). Microtia is a congenital deformity of the outer ear and occurs in approximately one in 8'000-10'000 births. It is characterized by a small, abnormally shaped outer ear. It can be unilateral or bilateral. Syndromic forms of microtia occur in conjunction with other abnormalities. The most common associated malformations is the cleft palate, a congenital fissure of the soft and/or hard palate due to faulty fusion. Defects in HOXA2 are a cause of autosomal- recessive bilateral microtia, mixed symmetrical severe to profound hearing impairment and partial cleft palate. Belongs to the Antp homeobox family. Proboscipedia subfamily.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 7p15.2

Cellular Component: nucleoplasm

Molecular Function: sequence-specific DNA binding; transcription factor activity

Biological Process: transcription, DNA-dependent; motor axon guidance; embryonic viscerocranium morphogenesis; negative regulation of transcription from RNA polymerase II promoter; cell fate determination; middle ear morphogenesis; osteoblast development; anterior/posterior pattern formation; segment specification; negative regulation of neuron differentiation; dorsal/ventral pattern formation; rhombomere 2 development; negative regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; rhombomere 3 morphogenesis; brain segmentation

Disease: Microtia, Hearing Impairment, And Cleft Palate

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