Full Product Name
2A5G Polyclonal Antibody
Product Synonym Names
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; PP2A B subunit isoform B'-gamma; PP2A B subunit isoform B56-gamma; PP2A B subunit isoform PR61-gamma; PP2A B subunit isoform R5-gamma; Renal carcinoma antigen NY-REN-29; PPP2R5C; KIAA0044
Product Gene Name
anti-2A5G antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13362
Species Reactivity
Human, Mouse
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from human protein. at AA range: 360-440
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-2A5G antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-2A5G antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-2A5G antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for 2A5G. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001155197.1
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NCBI GenBank Nucleotide #
NM_001161725.1
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UniProt Primary Accession #
Q13362
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UniProt Secondary Accession #
Q14391; Q15060; Q15174; Q6ZN33; B4DYJ8; B5BUA5; F5GWP3[Other Products]
UniProt Related Accession #
Q13362[Other Products]
NCBI Official Full Name
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform e
NCBI Official Synonym Full Names
protein phosphatase 2 regulatory subunit B'gamma
NCBI Official Symbol
PPP2R5C [Similar Products]
NCBI Official Synonym Symbols
B56G; PR61G; B56gamma
[Similar Products]
NCBI Protein Information
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
UniProt Protein Name
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
UniProt Synonym Protein Names
PP2A B subunit isoform B'-gamma; PP2A B subunit isoform B56-gamma; PP2A B subunit isoform PR61-gamma; PP2A B subunit isoform R5-gamma; Renal carcinoma antigen NY-REN-29
UniProt Gene Name
PPP2R5C [Similar Products]
UniProt Synonym Gene Names
KIAA0044 [Similar Products]
NCBI Summary for 2A5G
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for 2A5G
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
Research Articles on 2A5G
1. PPP2R5C deletion or EGFR mutation that could be responsible for IER3/pERK overexpression was found in at least 8 cases (67% or more) of lung adenocarcinoma.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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