ACRBP, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Affinity purified

Liquid

100ug/100ul (lot specific)

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Small volumes of anti-ACRBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008]

Peptide ELISA (EIA), Western Blot, Immunohistochemistry (IHC)

Peptide ELISA titer: 1:10,000-80,000
Western blot analysis: 1:500-1,000
Immunohistochemistry: 1:100-500
Optimal dilutions/concentrations should be determined by the end user.

61,359 Da

acrosin binding protein

acrosin-binding protein; ACRBP; cancer/testis antigen 23; cancer/testis antigen OY-TES-1; proacrosin binding protein sp32

Acrosin-binding protein

ACRBP_HUMAN

The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008]

ACRBP: May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.

Protein type: Vesicle; Cell development/differentiation; Secreted, signal peptide; Cancer Testis Antigen (CTA); Secreted; Activator

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: acrosome; extracellular region; nucleus

(1) Okumura,H., Noguchi,Y., Uenaka,A., et al. Identification of an HLA-A24-restricted OY-TES-1 epitope recognized by cytotoxic T-cells. Microbiol. Immunol. 49 (11), 1009-1016 (2005)

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