Full Product Name
DMGDH Antibody
Product Synonym Names
dimethylglycine dehydrogenase,mitochondrial; EC 1.5.99.2; M2GD; ME2GLYDH
Product Gene Name
anti-DMGDH antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UI17
Specificity
DMGDH antibody detects endogenous levels of total DMGDH protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from C-terminal of human DMGDH.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-DMGDH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-DMGDH antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-DMGDH antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-DMGDH antibody
WB: 1:500~1:1000
ELISA: 1:20000
Western Blot (WB) of anti-DMGDH antibody
Western blot analysis of extracts from HT-29 cells and A549 cells, using DMGDH antibody.
NCBI/Uniprot data below describe general gene information for DMGDH. It may not necessarily be applicable to this product.
NCBI Accession #
NP_037523.2
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NCBI GenBank Nucleotide #
NM_013391.3
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UniProt Primary Accession #
Q9UI17
[Other Products]
UniProt Secondary Accession #
B2RBN0; B4E1J9[Other Products]
UniProt Related Accession #
Q9UI17[Other Products]
Molecular Weight
45,079 Da
NCBI Official Full Name
dimethylglycine dehydrogenase, mitochondrial
NCBI Official Synonym Full Names
dimethylglycine dehydrogenase
NCBI Official Symbol
DMGDH [Similar Products]
NCBI Official Synonym Symbols
DMGDHD; ME2GLYDH
[Similar Products]
NCBI Protein Information
dimethylglycine dehydrogenase, mitochondrial
UniProt Protein Name
Dimethylglycine dehydrogenase, mitochondrial
UniProt Synonym Protein Names
ME2GLYDH
Protein Family
Dimethylglycine dehydrogenase
UniProt Gene Name
DMGDH [Similar Products]
NCBI Summary for DMGDH
This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for DMGDH
Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro.
Product References and Citations for anti-DMGDH antibody
Binzak B.A., Mol. Genet. Metab. 69:181-187(2000). Binzak B.A., Am. J. Hum. Genet. 68:839-847(2001). Moolenaar S.H., Clin. Chem. 45:459-464(1999).
Research Articles on DMGDH
1. In nonalcoholic fatty liver disease patient, the missense variant p.Ser646Pro (rs1805074) in DMGDH gene was significantly associated with disease severity and circulating levels of dimethylglycine.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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