Full Product Name
DMGDH Antibody
Product Synonym Names
Purified Rabbit Polyclonal Antibody (Pab)
Product Gene Name
anti-DMGDH antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UI17
Form/Format
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Antigen Type
A Synthesized Peptide
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-DMGDH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-DMGDH antibody
Metabolism; Neuroscience; Signal Transduction
Applications Tested/Suitable for anti-DMGDH antibody
Western Blot (WB)
Application Notes for anti-DMGDH antibody
WB ~~1:1000
Western Blot (WB) of anti-DMGDH antibody
Anti-DMGDH Antibody at 1:1000 dilution + human liver lysate
Lysates/proteins at 20 ug per lane.
Secondary
Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution.
Predicted band size : 97 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.
NCBI/Uniprot data below describe general gene information for DMGDH. It may not necessarily be applicable to this product.
NCBI Accession #
NP_037523.2
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NCBI GenBank Nucleotide #
NM_013391.3
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UniProt Primary Accession #
Q9UI17
[Other Products]
UniProt Secondary Accession #
B2RBN0; B4E1J9[Other Products]
UniProt Related Accession #
Q9UI17[Other Products]
NCBI Official Full Name
dimethylglycine dehydrogenase, mitochondrial
NCBI Official Synonym Full Names
dimethylglycine dehydrogenase
NCBI Official Symbol
DMGDH [Similar Products]
NCBI Official Synonym Symbols
DMGDHD; ME2GLYDH
[Similar Products]
NCBI Protein Information
dimethylglycine dehydrogenase, mitochondrial
UniProt Protein Name
Dimethylglycine dehydrogenase, mitochondrial
UniProt Synonym Protein Names
ME2GLYDH
Protein Family
Dimethylglycine dehydrogenase
UniProt Gene Name
DMGDH [Similar Products]
UniProt Entry Name
M2GD_HUMAN
NCBI Summary for DMGDH
This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for DMGDH
DMGDH: Defects in DMGDH are the cause of DMGDH deficiency (DMGDHD). DMGDHD is a disorder characterized by fish odor, muscle fatigue with increased serum creatine kinase. Biochemically it is characterized by an increase of N,N- dimethylglycine (DMG) in serum and urine. Belongs to the GcvT family.
Protein type: Oxidoreductase; Amino Acid Metabolism - glycine, serine and threonine; EC 1.5.8.4; Mitochondrial
Chromosomal Location of Human Ortholog: 5q14.1
Cellular Component: mitochondrial matrix
Molecular Function: electron carrier activity; dimethylglycine dehydrogenase activity
Biological Process: glycine metabolic process; choline metabolic process; betaine catabolic process
Disease: Dimethylglycine Dehydrogenase Deficiency
Product References and Citations for anti-DMGDH antibody
Binzak B.A.,et al.Mol. Genet. Metab. 69:181-187(2000). Binzak B.A.,et al.Am. J. Hum. Genet. 68:839-847(2001). Ota T.,et al.Nat. Genet. 36:40-45(2004). Schmutz J.,et al.Nature 431:268-274(2004). Moolenaar S.H.,et al.Clin. Chem. 45:459-464(1999).
Research Articles on DMGDH
1. Genetic variation of DMGDH was associated with higher plasma insulin, increased insulin resistance and increased risk of incident diabetes.
Precautions
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Disclaimer
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