Full Product Name
DMGDH Rabbit Polyclonal
Product Gene Name
anti-DMGDH antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Dimethylglycine dehydrogenase
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-DMGDH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DMGDH antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for DMGDH. It may not necessarily be applicable to this product.
NCBI Accession #
AAH22388.1
[Other Products]
UniProt Secondary Accession #
B2RBN0; B4E1J9[Other Products]
UniProt Related Accession #
Q9UI17[Other Products]
Molecular Weight
45,079 Da
NCBI Official Full Name
DMGDH protein, partial
NCBI Official Synonym Full Names
dimethylglycine dehydrogenase
NCBI Official Symbol
DMGDH [Similar Products]
NCBI Official Synonym Symbols
DMGDHD; ME2GLYDH
[Similar Products]
NCBI Protein Information
dimethylglycine dehydrogenase, mitochondrial
UniProt Protein Name
Dimethylglycine dehydrogenase, mitochondrial
UniProt Synonym Protein Names
ME2GLYDH
Protein Family
Dimethylglycine dehydrogenase
UniProt Gene Name
DMGDH [Similar Products]
UniProt Entry Name
M2GD_HUMAN
NCBI Summary for DMGDH
This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for DMGDH
DMGDH: Defects in DMGDH are the cause of DMGDH deficiency (DMGDHD). DMGDHD is a disorder characterized by fish odor, muscle fatigue with increased serum creatine kinase. Biochemically it is characterized by an increase of N,N- dimethylglycine (DMG) in serum and urine. Belongs to the GcvT family.
Protein type: EC 1.5.8.4; Mitochondrial; Amino Acid Metabolism - glycine, serine and threonine; Oxidoreductase
Chromosomal Location of Human Ortholog: 5q14.1
Cellular Component: mitochondrial matrix
Molecular Function: dimethylglycine dehydrogenase activity; electron carrier activity
Biological Process: betaine catabolic process; choline catabolic process; choline metabolic process; glycine metabolic process
Disease: Dimethylglycine Dehydrogenase Deficiency
Research Articles on DMGDH
1. In agreement with previous studies, we show that the genetic variant rs921943 in DMGDH is significantly associated with selenium status in United Kingdom pregnant women.
Precautions
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Disclaimer
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