Product Name
ATP1A3, cDNA Clone
Full Product Name
ATP1A3 cDNA Clone
Product Gene Name
ATP1A3 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgggggaca agaaagatga caaggactca cccaagaaga acaagggcaa ggagcgccgg gacctggatg acctcaagaa ggaggtggct atgacagagc acaagatgtc agtggaagag gtctgccgga aatacaacac agactgtgtg cagggtttga cccacagcaa agcccaggag atcctggccc gggatgggcc taacgcactc acgccaccgc ctaccacccc agagtgggtc aagttttgcc ggcagctctt cgggggcttc tccatcctgc tgtggatcgg ggctatcctc tgcttcctgg cctacggtat ccaggcgggc accgaggacg acccctctgg tgacaacctg tacctgggca tcgtgctggc ggccgtggtg atcatcactg gctgcttctc ctactaccag gaggccaaga gctccaagat catggagtcc ttcaagaaca tggtgcccca gcaagccctg gtgatccggg aaggtgagaa gatgcaggtg aacgctgagg aggtggtggt cggggacctg gtggagatca agggtggaga ccgagtgcca gctgacctgc ggatcatctc agcccacggc tgcaaggtgg acaactcctc cctgactggc gaatccgagc cccagactcg ctctcccgac tgcacgcacg acaacccctt ggagactcgg aacatcacct tcttttccac caactgtgtg gaaggcacgg ctcggggcgt ggtggtggcc acgggcgacc gcactgtcat gggccgtatc gccaccctgg catcagggct ggaggtgggc aagacgccca tcgccatcga gattgagcac ttcatccagc tcatcaccgg cgtggctgtc ttcctgggtg tctccttctt catcctctcc ctcattctcg gatacacctg gcttgaggct gtcatcttcc tcatcggcat catcgtggcc aatgtcccag agggtctgct ggccactgtc actgtgtgtc tgacgctgac cgccaagcgc atggcccgga agaactgcct ggtgaagaac ctggaggctg tagaaaccct gggctccacg tccaccatct gctcagataa gacagggacc ctcactcaga accgcatgac agtcgcccac atgtggtttg acaaccagat ccacgaggct gacaccactg aggaccagtc agggacctca tttgacaaga gttcgcacac ctgggtggcc ctgtctcaca tcgctgggct ctgcaatcgc gctgtcttca agggtggtca ggacaacatc cctgtgctca agagggatgt ggctggggat gcgtctgagt ctgccctgct caagtgcatc gagctgtcct ctggctccgt gaagctgatg cgtgaacgca acaagaaagt ggctgagatt cccttcaatt ccaccaacaa ataccagctc tccatccatg agaccgagga ccccaacgac aaccgatacc tgctggtgat gaagggtgcc cccgagcgca tcctggaccg ctgctccacc atcctgctac agggcaagga gcagcctctg gacgaggaaa tgaaggaggc cttccagaat gcctaccttg agctcggtgg cctgggcgag cgcgtgcttg gtttctgcca ttattacctg cccgaggagc agttccccaa gggctttgcc ttcgactgtg atgacgtgaa cttcaccacg gacaacctct gctttgtggg cctcatgtcc atgatcgacc caccccgggc agccgtccct gacgcggtgg gcaagtgtcg cagcgcaggc atcaaggtca tcatggtcac cggcgatcac cccatcacgg ccaaggccat tgccaagggt gtgggcatca tctctgaggg caacgagact gtggaggaca tcgccgcccg gctcaacatt cccgtcagcc aggttaaccc ccgggatgcc aaggcctgcg tgatccacgg caccgacctc aaggacttca cctccgagca aatcgacgag atcctgcaga atcacaccga gatcgtcttc gcccgcacat ccccccagca gaagctcatc attgtggagg gctgtcagag acagggtgca attgtggctg tgaccgggga tggtgtgaac gactcccccg ctctgaagaa ggccgacatt ggggtggcca tgggcatcgc tggctctgac gtctccaagc aggcagctga catgatcctg ctggacgaca actttgcctc catcgtcaca ggggtggagg agggccgcct gatcttcgac aacctaaaga agtccattgc ctacaccctg accagcaata tcccggagat cacgcccttc ctgctgttca tcatggccaa catcccgctg cccctgggca ccatcaccat cctctgcatc gatctgggca ctgacatggt ccctgccatc tcactggcgt acgaggctgc cgaaagcgac atcatgaaga gacagcccag gaacccgcgg acggacaaat tggtcaatga gagactcatc agcatggcct acgggcagat tggaatgatc caggctctcg gtggcttctt ctcttacttt gtgatcctgg cagaaaatgg cttcttgccc ggcaacctgg tgggcatccg gctgaactgg gatgaccgca ccgtcaatga cctggaagac agttacgggc agcagtggac atacgagcag aggaaggtgg tggagttcac ctgccacacg gccttctttg tgagcatcgt tgtcgtccag tgggccgatc tgatcatctg caagacccgg aggaactcgg tcttccagca gggcatgaag aacaagatcc tgatcttcgg gctgtttgag gagacggccc tggctgcctt cctgtcctac tgccccggca tggacgtggc cctgcgcatg taccctctca agcccagctg gtggttctgt gccttcccct acagtttcct catcttcgtc tacgacgaaa tccgcaaact catcctgcgc aggaacccag ggggttgggt ggagaaggaa acctactact ga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ATP1A3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ATP1A3. It may not necessarily be applicable to this product.
NCBI Accession #
BC009282
[Other Products]
UniProt Secondary Accession #
Q16732; Q16735; Q969K5; B7Z2T0; B7Z401; F5H6J6[Other Products]
UniProt Related Accession #
P13637[Other Products]
Molecular Weight
113,059 Da
NCBI Official Full Name
Homo sapiens ATPase, Na+/K+ transporting, alpha 3 polypeptide, mRNA
NCBI Official Synonym Full Names
ATPase Na+/K+ transporting subunit alpha 3
NCBI Official Symbol
ATP1A3 [Similar Products]
NCBI Official Synonym Symbols
RDP; AHC2; CAPOS; DYT12; ATP1A1
[Similar Products]
NCBI Protein Information
sodium/potassium-transporting ATPase subunit alpha-3
UniProt Protein Name
Sodium/potassium-transporting ATPase subunit alpha-3
UniProt Synonym Protein Names
Na(+)/K(+) ATPase alpha(III) subunit; Sodium pump subunit alpha-3
Protein Family
Sodium/potassium-transporting ATPase
UniProt Gene Name
ATP1A3 [Similar Products]
UniProt Synonym Gene Names
Na(+)/K(+) ATPase alpha-3 subunit [Similar Products]
UniProt Entry Name
AT1A3_HUMAN
NCBI Summary for ATP1A3
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for ATP1A3
ATP1A3: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Defects in ATP1A3 are the cause of dystonia type 12 (DYT12); also known as rapid-onset dystonia parkinsonism (RDP). DYT12 is an autosomal dominant dystonia- parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT12 patients develop dystonia and parkinsonism between 15 and 45 years of age. The disease is characterized by an unusually rapid evolution of signs and symptoms. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
Protein type: Transporter; Endoplasmic reticulum; Transporter, ion channel; Membrane protein, multi-pass; EC 3.6.3.9; Hydrolase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.31
Cellular Component: endoplasmic reticulum; Golgi apparatus; plasma membrane; sodium:potassium-exchanging ATPase complex; synapse
Molecular Function: chaperone binding; sodium:potassium-exchanging ATPase activity
Biological Process: ATP hydrolysis coupled proton transport; cellular potassium ion homeostasis; cellular sodium ion homeostasis; potassium ion import
Disease: Alternating Hemiplegia Of Childhood 2; Cerebellar Ataxia, Areflexia, Pes Cavus, Optic Atrophy, And Sensorineural Hearing Loss; Dystonia 12
Research Articles on ATP1A3
1. Our results, demonstrate a highly variable clinical phenotype in patients with alternating hemiplegia of childhood that correlates with certain mutations and possibly clusters within the ATPase Na+/K+ transporting subunit alpha 3 gene.
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Disclaimer
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