Product Name
Acetylcholine receptor subunit beta (CHRNB1), Recombinant Protein
Full Product Name
Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial
Product Gene Name
CHRNB1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
24-244
Sequence
SEAEGRLREK LFSGYDSSVR PAREVGDRVR VSVGLILAQL ISLNEKDEEM STKVYLDLEW TDYRLSWDPA EHDGIDSLRI TAESVWLPDV VLLNNNDGNF DVALDISVVV SSDGSVRWQP PGIYRSSCSI QVTYFPFDWQ NCTMVFSSYS YDSSEVSLQT GLGPDGQGHQ EIHIHEGTFI ENGQWEIIHK PSRLIQPPGD PRGGREGQRQ EVIFYLIIRR K
3D Structure
ModBase 3D Structure for P11230
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CHRNB1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CHRNB1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000738.2
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NCBI GenBank Nucleotide #
NM_000747.2
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UniProt Primary Accession #
P11230
[Other Products]
UniProt Secondary Accession #
Q8IZ46; Q96FB8; B7Z5H1[Other Products]
UniProt Related Accession #
P11230[Other Products]
Molecular Weight
49,083 Da
NCBI Official Full Name
acetylcholine receptor subunit beta
NCBI Official Synonym Full Names
cholinergic receptor nicotinic beta 1 subunit
NCBI Official Symbol
CHRNB1 [Similar Products]
NCBI Official Synonym Symbols
ACHRB; CHRNB; CMS1D; CMS2A; CMS2C; SCCMS
[Similar Products]
NCBI Protein Information
acetylcholine receptor subunit beta
UniProt Protein Name
Acetylcholine receptor subunit beta
Protein Family
Acetylcholine receptor
UniProt Gene Name
CHRNB1 [Similar Products]
UniProt Synonym Gene Names
ACHRB; CHRNB [Similar Products]
NCBI Summary for CHRNB1
The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. [provided by RefSeq, Jul 2008]
UniProt Comments for CHRNB1
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Research Articles on CHRNB1
1. Study traced the cause of congenital myasthenia syndrome in unrelated patients with dominant missense mutations in the M2 domain of AChR. A valine residue is replaced by a smaller alanine either in the epsilon subunit or an equivalent position in the beta one. Also, each valine in the valine ring was found to contribute to channel kinetics equally, and the valine ring has bee optimized during evolution to govern channe...
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
