Full Product Name
HOXA2 Antibody
Product Synonym Names
HOX1K; MCOHI
Product Gene Name
anti-HOXA2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
AC004079 Genomic DNA
3D Structure
ModBase 3D Structure for O43364
Specificity
The antibody detects endogenous levels of total HOXA2 protein.
Purity/Purification
Antigen affinity purification
Form/Format
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
0.6mg/ml (lot specific)
Immunogen
Synthetic peptide of human HOXA2
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-HOXA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HOXA2 antibody
This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development.
Product Categories/Family for anti-HOXA2 antibody
Total protein Ab
Applications Tested/Suitable for anti-HOXA2 antibody
Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-HOXA2 antibody
Western Blot: 1:200-1000
Immunohistochemistry: 1: 20-100
SDS-Page of anti-HOXA2 antibody
Gel: 8%SDS-PAGE Lysate: 40 ug, Lane 1-2: Human fetal muscle tissue and PC-3 cell, Primary antibody:HOXA2 antibody at dilution 1/250 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
Immunohistochemistry (IHC) of anti-HOXA2 antibody
The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using HOXA2 Antibody at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200)
NCBI/Uniprot data below describe general gene information for HOXA2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006726.1
[Other Products]
NCBI GenBank Nucleotide #
NM_006735.3
[Other Products]
UniProt Primary Accession #
O43364
[Other Products]
UniProt Secondary Accession #
A1L4K3; B2RMW3[Other Products]
UniProt Related Accession #
O43364[Other Products]
Molecular Weight
41,002 Da
NCBI Official Full Name
homeobox protein Hox-A2
NCBI Official Synonym Full Names
homeobox A2
NCBI Official Symbol
HOXA2 [Similar Products]
NCBI Official Synonym Symbols
HOX1K; MCOHI
[Similar Products]
NCBI Protein Information
homeobox protein Hox-A2
UniProt Protein Name
Homeobox protein Hox-A2
UniProt Synonym Protein Names
Homeobox protein Hox-1K
Protein Family
Homeobox protein
UniProt Gene Name
HOXA2 [Similar Products]
UniProt Synonym Gene Names
HOX1K [Similar Products]
UniProt Entry Name
HXA2_HUMAN
NCBI Summary for HOXA2
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. [provided by RefSeq, Jul 2008]
UniProt Comments for HOXA2
HOXA2: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXA2 are a cause of microtia hearing impairment and cleft palate (MHICP). Microtia is a congenital deformity of the outer ear and occurs in approximately one in 8'000-10'000 births. It is characterized by a small, abnormally shaped outer ear. It can be unilateral or bilateral. Syndromic forms of microtia occur in conjunction with other abnormalities. The most common associated malformations is the cleft palate, a congenital fissure of the soft and/or hard palate due to faulty fusion. Defects in HOXA2 are a cause of autosomal- recessive bilateral microtia, mixed symmetrical severe to profound hearing impairment and partial cleft palate. Belongs to the Antp homeobox family. Proboscipedia subfamily.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 7p15.2
Cellular Component: nucleoplasm
Disease: Microtia, Hearing Impairment, And Cleft Palate
Research Articles on HOXA2
1. The Hoxa2-mediated decay of RCHY1 involves both the 19S and 20S proteasome complexes
Precautions
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Disclaimer
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