Calcium Sensing Receptor, Polyclonal Antibody

Anti -Calcium Sensing Receptor (CASR)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 3; NC_000003.11 (121903181..122005344). Location: 3q13

Polyclonal

IgG

Rabbit

Recognizes human CaSR. Species Sequence Homology

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as liquid in PBS, pH 7.4, 0.1% BSA.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-CASR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The divalent cations (Ca2+ and Mg2+) are important for a multitude of cellular functions. A G-protein coupled receptor, termed calcium sensing receptor, responds to extracellular calcium and mediates several of the known effects of Ca on parathyroid and renal functions. CaSR is expressed in a number of tissues including thyroid C-cells,. Brain, and GI tract. Ca2+ acts as first messenger via CaSR-mediated activation of second messenger systems (e.g., phospholipase C and A2, cAMP) altering cellular physiology. Several mutations in the human CaSR gene have been identified in several inherited diseases of calcium metabolism such as familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism

Antibodies; Abs to Receptors

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Suitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry.
Dilution: Western Blot: 1-10ug/ml using ECL.
ELISA: 0.5-1ug/ml. Control peptide can be used to coat plates at 1ug/ml.
Immunofluorescence: 1-20ug/ml
Immunohistochemistry (Paraformaldehyde fixed): 1-20ug/ml

55,961 Da[Similar Products]

calcium-sensing receptor

extracellular calcium-sensing receptor; OTTHUMP00000215576; OTTHUMP00000215577; parathyroid Ca(2+)-sensing receptor 1; parathyroid cell calcium-sensing receptor

Calcium sensing receptor

Q2F3K1_HUMAN

The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq]

CaR: a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described.

Protein type: Membrane protein, multi-pass; Motility/polarity/chemotaxis; GPCR, family 3; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding; phosphoinositide phospholipase C activity

Biological Process: cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; ossification; anatomical structure morphogenesis; metabolic process; chemosensory behavior; detection of calcium ion

Disease: Hypocalciuric Hypercalcemia, Familial, Type I; Hyperparathyroidism, Neonatal Severe; Epilepsy, Idiopathic Generalized, Susceptibility To, 8; Hypocalcemia, Autosomal Dominant 1

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