Product Name
Bestrophin (BEST1), Polyclonal Antibody
Full Product Name
Bestrophin 1 Antibody BIOTIN-Conjugated
Product Synonym Names
ARB; BEST 1; BEST; Best disease; Best macular dystrophy; Best1V1Delta2; BMD; mBest1; RP50; TU15B; Vitelliform macular dystrophy 2; Vitelliform macular dystrophy protein 2; VMD 2 antibody
Product Gene Name
anti-BEST1 antibody
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Antibody/Peptide Pairs
Bestrophin peptide (MBS542562) is used for blocking the activity of Bestrophin antibody (MBS541153)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for A5H7G8
Species Reactivity
Dog, Human, Monkey
Form/Format
BIOTIN-Conjugated
Concentration
0.55-0.75 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken within amino acid region 530-580 on canine Bestrophin 1 protein.
Expression
Predominantly expressed in the basolateral membrane of the retinal pigment epithelium
Molecular Function
Ion transport; Sensory transduction; Transport; Vision
Structure
Tetramer or pentamers
Subcellular Location
Cell membrane; Multi-pass membrane protein; Basolateral cell membrane
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-BEST1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BEST1 antibody
Forms calcium sensitive chloride channels. Highly permeable to bicarbonate.
Applications Tested/Suitable for anti-BEST1 antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-BEST1 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:150
Western Blot: 1:500
NCBI/Uniprot data below describe general gene information for BEST1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001091014.1
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NCBI GenBank Nucleotide #
NM_001097545.1
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UniProt Primary Accession #
A5H7G8
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UniProt Secondary Accession #
F1Q123[Other Products]
Molecular Weight
66,298 Da[Similar Products]
NCBI Official Full Name
bestrophin-1
NCBI Official Symbol
BEST1 [Similar Products]
NCBI Official Synonym Symbols
VMD2
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NCBI Protein Information
bestrophin-1
UniProt Protein Name
Bestrophin
UniProt Synonym Protein Names
Bestrophin
Protein Family
Bestrophin
UniProt Gene Name
VMD2 [Similar Products]
UniProt Entry Name
A5H7G8_CANLF
Research Articles on BEST1
1. Bestrophinopathies are a group of inherited retinal disorders primarily caused by point mutations scattered throughout the BEST1 gene.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
