A Disintegrin And Metalloproteinase With Thrombospondin 7 (ADAMTS7), Polyclonal

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 15; NC_000015.9 (79051545..79103805, complement). Location: 15q24.2

Polyclonal

IgG

Rabbit

The antibody is a rabbit polyclonal antibody raised against ADAMTS7 conjugated to biotin. It has been selected for its ability to recognize ADAMTS7 in immunohistochemical staining andwestern blotting.

Affinity Chromatography

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.

200ug/ml (lot specific)

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of anti-ADAMTS7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Biotin Antibody

Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)

Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

184,095 Da

ADAM metallopeptidase with thrombospondin type 1 motif, 7

A disintegrin and metalloproteinase with thrombospondin motifs 7; COMPase; a disintegrin and metalloprotease with thrombospondin motifs-7 preproprotein; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7

A disintegrin and metalloproteinase with thrombospondin motifs 7

ADAM-TS 7; ADAM-TS7; ADAMTS-7  [Similar Products]

ATS7_HUMAN

The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two C-terminal TS motifs. [provided by RefSeq, Jul 2008]

ADAMTS7: Metalloprotease that may play a role in the degradation of COMP.

Protein type: Secreted, signal peptide; Cell surface; Secreted; EC 3.4.24.-; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 15q24.2

Cellular Component: proteinaceous extracellular matrix; cell surface; endoplasmic reticulum lumen

Molecular Function: protein binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity

Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; proteolysis involved in cellular protein catabolic process; negative regulation of chondrocyte differentiation; post-translational protein modification

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