Bile salt export pump, ELISA Kit

Bile salt export pump; ATP-binding cassette sub-family B member 11; Sister of P-glycoprotein; Abcb11; Bsep; Spgp

For Research Use Only. Not for use in diagnostic procedures.

For long term storage, please store the entire kit at -20 degree C.

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of Abcb11 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2886039 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Bile salt export pump (Abcb11) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Abcb11. The ELISA analytical biochemical technique of the MBS2886039 kit is based on Abcb11 antibody-Abcb11 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Abcb11 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Abcb11. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

146,258 Da

ATP binding cassette subfamily B member 11

bile salt export pump

Bile salt export pump

Bsep; Spgp  [Similar Products]

ABCBB_RAT

acts as an ATP-dependent bile salt export pump; transports taurochenodeoxycholate, taurocholate, and other bile salts [RGD, Feb 2006]

ABCB11: Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis type 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease. Defects in ABCB11 are the cause of benign recurrent intrahepatic cholestasis type 2 (BRIC2). BRIC is characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration and patients are asymptomatic between episodes, both clinically and biochemically. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Protein type: Hydrolase; Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ABC family

Cellular Component: apical part of cell; apical plasma membrane; Golgi apparatus; Golgi membrane; integral to membrane; intercellular canaliculus; membrane; plasma membrane

Molecular Function: ATP binding; ATPase activity, coupled to transmembrane movement of substances; canalicular bile acid transmembrane transporter activity; drug transporter activity; protein binding

Biological Process: bile acid and bile salt transport; canalicular bile acid transport; drug export; multidrug transport; response to drug; response to estrogen stimulus; response to oxidative stress; transmembrane transport

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