PHD finger protein 6, ELISA Kit

Human PHD finger protein 6 (PHF6) ELISA kit; AC004383.6; BORJ; MGC14797; PHD-like zinc finger protein; PHD finger protein 6

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of PHF6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9338382 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the PHD finger protein 6 (PHF6) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PHF6. The ELISA analytical biochemical technique of the MBS9338382 kit is based on PHF6 antibody-PHF6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PHF6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PHF6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

41,290 Da

PHD finger protein 6

PHD finger protein 6; centromere protein 31; PHD-like zinc finger protein

PHD finger protein 6

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PHF6_HUMAN

This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus. Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by mental retardation, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears. Alternate splicing results in multiple transcript variants, encoding different isoforms. [provided by RefSeq, Jun 2010]

PHF6: May play a role in transcriptional regulation. Defects in PHF6 are the cause of Boerjeson-Forssman- Lehmann syndrome (BFLS); also known as Boerjeson- Forssman syndrome (BORJ). BFLS is a X-linked recessive disorder characterized by moderate to severe mental retardation, epilepsy, hypogonadism, hypometabolism, obesity with marked gynecomastia, swelling of subcutaneous tissue of the face, narrow palpebral fissure and large but not deformed ears. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus; Unknown function

Chromosomal Location of Human Ortholog: Xq26.3

Cellular Component: nucleoplasm; nucleolus; nucleus

Molecular Function: tubulin binding; ribonucleoprotein binding; protein binding; enzyme binding; DNA binding; histone binding; zinc ion binding; histone deacetylase binding; phosphoprotein binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent

Disease: Borjeson-forssman-lehmann Syndrome

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