ADAMTS4, Polyclonal Antibody

Anti -ADAMTS4, CT (A Disintegrin And Metalloproteinase with Thrombospondin Motif 4, ADAM Metallopeptidase with Thrombospondin Type 1 Motif 4, ADAMTS-4, ADAM-TS4, ADAM-TS 4, ADAMTS-4 Precursor, ADMP-1, Aggrecanase I, Aggrecanase 1, KIAA0688, UNQ769/PRO1563)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 1; NC_000001.10 (161159538..161168845, complement). Location: 1q21-q23

Polyclonal

IgG

Rabbit

Recognizes human ADAMTS 4 (C-TERMINAL).

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid, 0.05% sodium azide, 50% glycerol.

May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-ADAMTS4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antibodies; Abs to Matrix Metalloproteinases

Western Blot (WB), Immunohistochemistry (IHC)

Suitable for use in Immunohistochemistry (frozen) and Western Blot.
Dilution: Western Blot: 1:1,000

90,197 Da[Similar Products]

ADAM metallopeptidase with thrombospondin type 1 motif, 4

A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; OTTHUMP00000032249; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4

A disintegrin and metalloproteinase with thrombospondin motifs 4

KIAA0688  [Similar Products]

ATS4_HUMAN

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq]

ADAMTS4: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

Protein type: Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide; EC 3.4.24.82

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: peptidase activity; protein binding; protease binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response to bacterium; proteolysis; skeletal development

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