ADAMTS5, Polyclonal Antibody

Anti -ADAMTS5, CT (A Disintegrin And Metalloproteinase with Thrombospondin Motif 5, A Disintegrin-like and Metalloprotease (Reprolysin type) with Thrombospondin Type 1 Motif 5, ADAM Metallopeptidase with Thrombospondin Type 1 Motif 5, ADAM-TS5, ADAM-TS 5, A Dis

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 21; NC_000021.8 (28290231..28339439, complement). Location: 21q21.3

Polyclonal

IgG

Rabbit

Recognizes Metalloproteinase ADAMTS-5.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in PBS, 0.05% sodium azide, 50% glycerol.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 

Small volumes of anti-ADAMTS5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antibodies; Abs to Matrix Metalloproteinases

Western Blot (WB)

Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000 when using colormetric substrates; 1:5000 for chemiluminescent substrates. Recognizes the zymogen of ADAMTS-5 at 120kD in reduced Western blots, activated forms at 73kD major bands and breakdown products at 50kD and 40kD in cell lysates.

101,718 Da[Similar Products]

ADAM metallopeptidase with thrombospondin type 1 motif, 5

A disintegrin and metalloproteinase with thrombospondin motifs 5; aggrecanase-2; OTTHUMP00000096353; a disintegrin and metalloproteinase with thrombospondin motifs 11; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)

A disintegrin and metalloproteinase with thrombospondin motifs 5

ADAMTS11; ADMP2  [Similar Products]

ATS5_HUMAN

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq]

ADAMTS5: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.

Protein type: Secreted; Extracellular matrix; Secreted, signal peptide; Protease; EC 3.4.24.-; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 21q21.3

Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum lumen; extracellular region

Molecular Function: integrin binding; protein binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity

Biological Process: extracellular matrix disassembly; protein amino acid O-linked glycosylation; extracellular matrix organization and biogenesis; cellular protein metabolic process; defense response to bacterium; post-translational protein modification; proteolysis

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