Product Name
Keratin 16 (KRT16), Monoclonal Antibody
Full Product Name
APC/Cy7 Linked Monoclonal Antibody to Keratin 16 (KRT16)
Product Synonym Names
CK16; NEPPK; Cytokeratin 16; Focal Non-Epidermolytic Palmoplantar Keratoderma; Keratin, type I cytoskeletal 16
Product Gene Name
anti-KRT16 antibody
[Similar Products]
Matching Pairs
Unconjugated Antibody: Keratin 16 (KRT16) Clone #D4 (MBS2001281)
APC-CY7 Conjugated Antibody: Keratin 16 (KRT16) Clone #D4 (MBS2107132)
Matching Pairs
Antibody: Keratin 16 (KRT16) Clone #D4 (MBS2107132)
Antigen: Keratin 16 (KRT16) (MBS2012380)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Glu117~Arg 419
3D Structure
ModBase 3D Structure for P08779
Specificity
The antibody is a Mouse monoclonal antibody raised against KRT16. It has been selected for its ability to recognize KRT16 in immunohistochemical staining and western blotting.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
500ug/ml (lot specific)
Preparation and Storage
Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months.
Avoid repeated freeze/thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customerâs specifications, please inquire.
Other Notes
Small volumes of anti-KRT16 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-KRT16 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
NCBI/Uniprot data below describe general gene information for KRT16. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005548.2
[Other Products]
NCBI GenBank Nucleotide #
NM_005557.4
[Other Products]
UniProt Primary Accession #
P08779
[Other Products]
UniProt Related Accession #
P08779[Other Products]
NCBI Official Full Name
keratin, type I cytoskeletal 16
NCBI Official Synonym Full Names
keratin 16
NCBI Official Symbol
KRT16 [Similar Products]
NCBI Official Synonym Symbols
K16; PC1; CK16; K1CP; NEPPK; FNEPPK; KRT16A
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NCBI Protein Information
keratin, type I cytoskeletal 16
UniProt Protein Name
Keratin, type I cytoskeletal 16
UniProt Synonym Protein Names
Cytokeratin-16; CK-16; Keratin-16
UniProt Gene Name
KRT16 [Similar Products]
UniProt Synonym Gene Names
KRT16A; CK-16; K16 [Similar Products]
UniProt Entry Name
K1C16_HUMAN
NCBI Summary for KRT16
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]
UniProt Comments for KRT16
K16: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6. K16 and K17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: cytoskeleton; intermediate filament; nucleus
Molecular Function: protein binding; structural constituent of cytoskeleton
Biological Process: epidermis development; intermediate filament cytoskeleton organization and biogenesis; cytoskeleton organization and biogenesis; keratinocyte migration; hair cycle; keratinocyte differentiation; cell proliferation; keratinization; morphogenesis of an epithelium; innate immune response; inflammatory response; negative regulation of cell migration; aging
Disease: Palmoplantar Keratoderma, Nonepidermolytic, Focal; Pachyonychia Congenita 1
Research Articles on KRT16
1. Study identified iRHOM2 as a novel regulator of K16 in humans and mice, with important implications for palmoplantar keratodermas, wound healing, inflammatory skin disease and cancers.
Precautions
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Disclaimer
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