Apobec1, Polyclonal Antibody

Anti -Apobec1, NT (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide 1, ABEDP, CDAR1, HEPR, Apolipoprotein B mRNA Editing Enzyme)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 12; NC_000012.11 (7801996..7818502, complement). Location: 12p13.1

Polyclonal

IgG

Rabbit

Recognizes human Apobec1. Species Crossreactivity: mouse.

Affinity Purified
Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, 0.09% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-APOBEC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

APOBEC1 is involved in the production of apolipoprotein B (apoB)-48 from apoB-100. The gene spans 18 kb and contains five exons, all of which are translated. Alternative splicing produces a variant transcript that lacks exon 2 and encodes a novel 36aa peptide. The exon 2-skipped transcript accounts for approximately 50% of APOBEC1 mRNA in the ***** small intestine and up to 90% of APOBEC1 mRNA in the developing gut. Exon 2-skipping may thus be a quantitatively important mechanism for regulating the expression of this gene in the gastrointestinal tract.

Antibodies; Abs to Enzymes, Cytidine Deaminase (APOBEC)

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

26,771 Da[Similar Products]

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1

C->U-editing enzyme APOBEC-1; OTTHUMP00000180598; apolipoprotein B mRNA-editing enzyme 1; apolipoprotein B mRNA editing enzyme complex-1

APOBEC1 protein

Q4VB33_HUMAN

This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. [provided by RefSeq]

APOBEC1: apolipoprotein B mRNA editing enzyme. Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. Expressed exclusively in the small intestine.

Protein type: Cell cycle regulation; EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding

Chromosomal Location of Human Ortholog: 12p13.1

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: protein binding; zinc ion binding; RNA binding; AU-rich element binding; cytidine deaminase activity

Biological Process: response to drug; mRNA stabilization; response to osmotic stress; regulation of cell proliferation; RNA processing; response to ethanol; cytidine to uridine editing; cellular response to insulin stimulus; response to zinc ion; lipoprotein biosynthetic process; lipoprotein transport; mRNA modification; response to gamma radiation; gene expression; cytidine deamination; lipid metabolic process; response to calcium ion; mRNA processing; defense response to virus

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