Full Product Name
GCH1 Antibody
Product Gene Name
anti-GCH1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P30793
Species Reactivity
Human, Mouse, Rat
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-GCH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GCH1 antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for GCH1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000152.1
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NCBI GenBank Nucleotide #
NM_000161.2
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UniProt Primary Accession #
P30793
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UniProt Secondary Accession #
Q6FHY7; Q9Y4I8[Other Products]
UniProt Related Accession #
P30793[Other Products]
Molecular Weight
25,775 Da
NCBI Official Full Name
GTP cyclohydrolase 1 isoform 1
NCBI Official Synonym Full Names
GTP cyclohydrolase 1
NCBI Official Symbol
GCH1 [Similar Products]
NCBI Official Synonym Symbols
GCH; DYT5; DYT14; DYT5a; GTPCH1; HPABH4B; GTP-CH-1
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NCBI Protein Information
GTP cyclohydrolase 1
UniProt Protein Name
GTP cyclohydrolase 1
UniProt Synonym Protein Names
GTP cyclohydrolase I; GTP-CH-I
Protein Family
GTP cyclohydrolase
UniProt Gene Name
GCH1 [Similar Products]
UniProt Synonym Gene Names
DYT5; GCH; GTP-CH-I [Similar Products]
NCBI Summary for GCH1
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008]
UniProt Comments for GCH1
Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown.
Research Articles on GCH1
1. No association between the GCH1 pain-protective haplotype and cervical dilation was found, but a previously demonstrated association with increased use of second-line analgesia was confirmed.
Precautions
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Disclaimer
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