Full Product Name
LAMP2 Antibody
Product Synonym Names
LAMPB; CD107b; LAMP-2; LGP110
Product Gene Name
anti-LAMP2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P13473
Specificity
The antibody detects endogenous levels of total LAMP2 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
2 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Fusion protein corresponding to a region derived from internal residues of human lysosomal-associated membrane protein 2
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-LAMP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LAMP2 antibody
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins
Product Categories/Family for anti-LAMP2 antibody
Total protein Ab
Applications Tested/Suitable for anti-LAMP2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-LAMP2 antibody
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200
Testing Data of anti-LAMP2 antibody
Gel: 10%SDS-PAGE Lysates (from left to right): Human placenta tissue Amount of lysate: 40ug per lane Primary antibody: 1/500 dilution Secondary antibody dilution: 1/8000 Exposure time: 30 seconds
Immunohistochemistry (IHC) of anti-LAMP2 antibody
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/40.
NCBI/Uniprot data below describe general gene information for LAMP2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001116078.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001122606.1
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UniProt Primary Accession #
P13473
[Other Products]
UniProt Secondary Accession #
Q16641; Q6Q3G8; Q96J30; Q99534; Q9UD93; A8K4X5; D3DTF0[Other Products]
UniProt Related Accession #
P13473[Other Products]
Molecular Weight
45,170 Da
NCBI Official Full Name
lysosome-associated membrane glycoprotein 2 isoform C
NCBI Official Synonym Full Names
lysosomal-associated membrane protein 2
NCBI Official Symbol
LAMP2 [Similar Products]
NCBI Official Synonym Symbols
LAMPB; CD107b; LAMP-2; LGP110
[Similar Products]
NCBI Protein Information
lysosome-associated membrane glycoprotein 2
UniProt Protein Name
Lysosome-associated membrane glycoprotein 2
UniProt Synonym Protein Names
CD107 antigen-like family member B; CD_antigen: CD107b
Protein Family
Lysosome-associated membrane glycoprotein
UniProt Gene Name
LAMP2 [Similar Products]
UniProt Synonym Gene Names
LAMP-2; Lysosome-associated membrane protein 2 [Similar Products]
UniProt Entry Name
LAMP2_HUMAN
NCBI Summary for LAMP2
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
UniProt Comments for LAMP2
LAMP2: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. Belongs to the LAMP family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq24
Cellular Component: phagocytic vesicle membrane; membrane; late endosome membrane; lysosomal membrane; lysosome; late endosome; integral to membrane; plasma membrane; platelet dense granule membrane
Molecular Function: protein domain specific binding; enzyme binding
Biological Process: platelet activation; platelet degranulation; protein stabilization; blood coagulation
Disease: Danon Disease
Research Articles on LAMP2
1. Data show thart lysosome-associated membrane protein type 2a (LAMP-2A) forms a coiled coil helix trimer in n-dodecylphosphocholine micelle, and protein substrates interact with its cytosolic tail.
Precautions
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