Full Product Name
ABCB11 Antibody
Product Gene Name
anti-ABCB11 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O95342
Other Notes
Small volumes of anti-ABCB11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-ABCB11 antibody
Western blot analysis ABCB11 using K562 whole cell lysates
NCBI/Uniprot data below describe general gene information for ABCB11. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003733.2
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NCBI GenBank Nucleotide #
NM_003742.4
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UniProt Primary Accession #
O95342
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UniProt Secondary Accession #
Q53TL2; Q9UNB2[Other Products]
UniProt Related Accession #
O95342[Other Products]
Molecular Weight
146,407 Da
NCBI Official Full Name
bile salt export pump
NCBI Official Synonym Full Names
ATP binding cassette subfamily B member 11
NCBI Official Symbol
ABCB11 [Similar Products]
NCBI Official Synonym Symbols
BSEP; PGY4; SPGP; ABC16; BRIC2; PFIC2; PFIC-2
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NCBI Protein Information
bile salt export pump
UniProt Protein Name
Bile salt export pump
UniProt Synonym Protein Names
ATP-binding cassette sub-family B member 11
Protein Family
ABC transporter B family
UniProt Gene Name
ABCB11 [Similar Products]
UniProt Synonym Gene Names
BSEP [Similar Products]
NCBI Summary for ABCB11
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCB11
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Research Articles on ABCB11
1. Residual function of BSEP as well as substrate specificity influence the therapeutic effectiveness of partial external biliary diversion in progressive familial intrahepatic cholestasis type 2.
Precautions
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Disclaimer
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