Product Name
NAB2, Blocking Peptide
Full Product Name
NAB2 Peptide
Product Gene Name
NAB2 blocking peptide
[Similar Products]
Product Synonym Gene Name
MADER; MGC75085[Similar Products]
NAB2 peptide (MBS3229202) is used for blocking the activity of NAB2 antibody (MBS3204235)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q15742
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of NAB2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
NAB2 blocking peptide
This is a synthetic peptide designed for use in combination with anti-NAB2 antibody made
Target Description: NAB2 is a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize withThis gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their
biological validity has not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Product Categories/Family for NAB2 blocking peptide
Peptide
Applications Tested/Suitable for NAB2 blocking peptide
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for NAB2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005958
[Other Products]
NCBI GenBank Nucleotide #
NM_005967
[Other Products]
UniProt Primary Accession #
Q15742
[Other Products]
UniProt Related Accession #
Q15742[Other Products]
NCBI Official Full Name
NGFI-A-binding protein 2 isoform 1
NCBI Official Synonym Full Names
NGFI-A binding protein 2
NCBI Official Symbol
NAB2 [Similar Products]
NCBI Official Synonym Symbols
MADER
[Similar Products]
NCBI Protein Information
NGFI-A-binding protein 2
UniProt Protein Name
NGFI-A-binding protein 2
UniProt Synonym Protein Names
EGR-1-binding protein 2; Melanoma-associated delayed early response protein
Protein Family
NGFI-A-binding protein
UniProt Gene Name
NAB2 [Similar Products]
UniProt Synonym Gene Names
MADER; Protein MADER [Similar Products]
UniProt Entry Name
NAB2_HUMAN
NCBI Summary for NAB2
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for NAB2
NAB2: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability. Belongs to the NAB family. 3 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component: nucleus
Molecular Function: transcription factor binding; transcription corepressor activity
Biological Process: Schwann cell differentiation; myelination; cell proliferation; nervous system development; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase III promoter; regulation of epidermis development; endochondral ossification
Research Articles on NAB2
1. Here, we demonstrate that pulmonary adenofibromas are neoplastic lesions harbouring NAB2-STAT6 fusion genes ,the molecular hallmark of solitary fibrous tumours.
Precautions
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Disclaimer
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