Elongation Factor RNA Polymerase II, Monoclonal Antibody

Anti -Elongation Factor RNA Polymerase II (C19orf17, DKFZp434I1916, ELL, ELL1, Men)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 19; NC_000019.9 (18553473..18632937, complement). Location: 19p13.1

Monoclonal

IgG1

8C128

Mouse

Recognizes human Elongation Factor RNA Polymerase II.

Affinity Purified
Purified by Protein G affinity chromatography.

Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-ELL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antibodies; Abs to Enzymes, Polymerase

Western Blot (WB)

Suitable for use in Western Blotting.
Dilution: Western Blotting: 1:1000-1:2000

68,265 Da[Similar Products]

elongation factor RNA polymerase II

RNA polymerase II elongation factor ELL; ELL gene (11-19 lysine-rich leukemia gene); eleven-nineteen lysine-rich leukemia protein

RNA polymerase II elongation factor ELL

C19orf17  [Similar Products]

ELL_HUMAN

ELL: Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein. Belongs to the ELL/occludin family.

Protein type: Nuclear receptor co-regulator; Oncoprotein; Transcription initiation complex

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: nucleoplasm; Cajal body; transcription elongation factor complex; nuclear speck

Molecular Function: protein binding; phosphatase binding

Biological Process: transcription from RNA polymerase II promoter; viral reproduction; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of viral transcription; in utero embryonic development; positive regulation of RNA elongation; RNA elongation from RNA polymerase II promoter; snRNA transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; gene expression; snRNA transcription from RNA polymerase III promoter

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