Product Name
NAB2, Blocking Peptide
Full Product Name
NAB2 Blocking Peptide
Product Synonym Names
MADER; NGFI-A-binding protein 2; EGR-1-binding protein 2; Melanoma-associated delayed early response protein; Protein MADER
Product Gene Name
NAB2 blocking peptide
[Similar Products]
NAB2 peptide (MBS8235355) is used for blocking the activity of NAB2 antibody (MBS8230887)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q15742
Species Reactivity
Human, Mouse, Rat, Bovine
Form/Format
Lyophilized powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Directions for Use
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of NAB2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
NAB2 blocking peptide
The peptide is used to block Anti-NAB2 Antibody reactivity.
Applications Tested/Suitable for NAB2 blocking peptide
Blocking (BL)
NCBI/Uniprot data below describe general gene information for NAB2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005958.1
[Other Products]
NCBI GenBank Nucleotide #
NM_005967.3
[Other Products]
UniProt Primary Accession #
Q15742
[Other Products]
UniProt Secondary Accession #
O76006; Q14797; B2RAK3[Other Products]
UniProt Related Accession #
Q15742[Other Products]
Molecular Weight
49,748 Da
NCBI Official Full Name
NGFI-A-binding protein 2
NCBI Official Synonym Full Names
NGFI-A binding protein 2 (EGR1 binding protein 2)
NCBI Official Symbol
NAB2 [Similar Products]
NCBI Official Synonym Symbols
MADER
[Similar Products]
NCBI Protein Information
NGFI-A-binding protein 2
UniProt Protein Name
NGFI-A-binding protein 2
UniProt Synonym Protein Names
EGR-1-binding protein 2; Melanoma-associated delayed early response protein; Protein MADER
Protein Family
NGFI-A-binding protein
UniProt Gene Name
NAB2 [Similar Products]
UniProt Synonym Gene Names
MADER; Protein MADER [Similar Products]
UniProt Entry Name
NAB2_HUMAN
NCBI Summary for NAB2
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their
biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for NAB2
NAB2: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability. Belongs to the NAB family. 3 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component: nucleus
Molecular Function: transcription corepressor activity; transcription factor binding
Biological Process: myelination; Schwann cell differentiation; nervous system development; cell proliferation; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase III promoter; regulation of epidermis development; endochondral ossification
Research Articles on NAB2
1. There was no association between solitary fibrous tumors with either NAB2 exon 4-STAT6 exon 2 or 3 fusion and tumors with other fusions regarding the frequency of mutations in the examined genes (P = .201).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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