Full Product Name
NAB2 Antibody
Product Synonym Names
EGR-1-binding protein 2; MADER; Melanoma-associated delayed early response protein; NGFI-A-binding protein 2
Product Gene Name
anti-NAB2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q15742
Species Reactivity
Human, Mouse
Specificity
NAB2 antibody detects endogenous levels of total NAB2 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human NAB2.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-NAB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-NAB2 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-NAB2 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-NAB2 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000
Testing Data of anti-NAB2 antibody
Peptide-+
Immunohistochemistry (IHC) of anti-NAB2 antibody
Immunohistochemistry analysis of paraffin-embedded human brain tissue using NAB2 antibody. Western blot analysis of extracts from HT-29 cells and RAW264.7 cells, using NAB2 antibody.
NCBI/Uniprot data below describe general gene information for NAB2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001317234.1
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NCBI GenBank Nucleotide #
NM_001330305.1
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UniProt Primary Accession #
Q15742
[Other Products]
UniProt Secondary Accession #
O76006; Q14797; B2RAK3[Other Products]
UniProt Related Accession #
Q15742[Other Products]
Molecular Weight
49,748 Da
NCBI Official Full Name
NGFI-A-binding protein 2 isoform 2
NCBI Official Synonym Full Names
NGFI-A binding protein 2
NCBI Official Symbol
NAB2 [Similar Products]
NCBI Official Synonym Symbols
MADER
[Similar Products]
NCBI Protein Information
NGFI-A-binding protein 2
UniProt Protein Name
NGFI-A-binding protein 2
UniProt Synonym Protein Names
EGR-1-binding protein 2; Melanoma-associated delayed early response protein; Protein MADER
Protein Family
NGFI-A-binding protein
UniProt Gene Name
NAB2 [Similar Products]
UniProt Synonym Gene Names
MADER; Protein MADER [Similar Products]
NCBI Summary for NAB2
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their
biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for NAB2
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability ().
Product References and Citations for anti-NAB2 antibody
Svaren J., Mol. Cell. Biol. 16:3545-3553(1996). Kirsch K.H., Oncogene 12:963-971(1996). Svaren J., Genomics 41:33-39(1997).
Research Articles on NAB2
1. Here, we demonstrate that pulmonary adenofibromas are neoplastic lesions harbouring NAB2-STAT6 fusion genes ,the molecular hallmark of solitary fibrous tumours.
Precautions
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Disclaimer
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