Signal transducer and activator of transcription 6, ELISA Kit

Signal transducer and activator of transcription 6; IL-4 Stat; STAT6

For Research Use Only. Not for use in diagnostic procedures.

For long term storage, please store the entire kit at -20 degree C.

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Small volumes of STAT6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2887572 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Signal transducer and activator of transcription 6 (STAT6) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing STAT6. The ELISA analytical biochemical technique of the MBS2887572 kit is based on STAT6 antibody-STAT6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect STAT6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, STAT6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

81,748 Da

signal transducer and activator of transcription 6, interleukin-4 induced

signal transducer and activator of transcription 6

Signal transducer and activator of transcription 6

STAT6_HUMAN

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

STAT6: transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: cytoplasm; cytosol; lipid raft; nuclear chromatin; nucleoplasm

Molecular Function: identical protein binding; protein binding; protein phosphatase binding; signal transducer activity; transcription factor activity

Biological Process: innate immune response; mammary gland epithelial cell proliferation; negative regulation of T-helper 2 type immune response; negative regulation of transcription from RNA polymerase II promoter; positive regulation of interferon type I production; positive regulation of isotype switching to IgE isotypes; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; signal transduction; T-helper 1 cell lineage commitment; transcription, DNA-dependent

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