FOXP2, Monoclonal Antibody

Forkhead box protein P2; CAG repeat protein 44; Trinucleotide repeat-containing gene 10 protein; FOXP2; CAGH44; TNRC10

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgM

533CT26.1.2

Mouse

This FOXP2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 657-684 amino acids from human FOXP2.

Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-FOXP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the forkhead/winged-helix
(FOX) family of transcription factors. It is expressed in fetal and
***** brain as well as in several other organs such as the lung and
gut. The protein product contains a FOX DNA-binding domain and a
large polyglutamine tract and is an evolutionarily conserved
transcription factor, which may bind directly to approximately 300
to 400 gene promoters in the human genome to regulate the
expression of a variety of genes. This gene is required for proper
development of speech and language regions of the brain during
embryogenesis, and may be involved in a variety of biological
pathways and cascades that may ultimately influence language
development. Mutations in this gene cause speech-language disorder
1 (SPCH1), also known as autosomal dominant speech and language
disorder with orofacial dyspraxia. Multiple alternative transcripts
encoding different isoforms have been identified in this gene.

Western Blot (WB), ELISA (EIA)

WB~~1:100~1600

FOXP2 Antibody(Ascites) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the FOXP2 antibody detected the FOXP2 protein (arrow).

79919

forkhead box P2

forkhead box protein P2

Forkhead box protein P2

CAGH44; TNRC10  [Similar Products]

FOXP2_HUMAN

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and ***** brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

FOXP2: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language. Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Isoform 1 and isoform 6 are expressed in ***** and fetal brain, caudate nucleus and lung. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: nucleus

Molecular Function: protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; metal ion binding; transcription factor activity

Biological Process: caudate nucleus development; skeletal muscle development; camera-type eye development; transcription, DNA-dependent; righting reflex; putamen development; negative regulation of transcription from RNA polymerase II promoter; vocal learning; post-embryonic development; smooth muscle development; positive regulation of mesenchymal cell proliferation; cerebellum development; cerebral cortex development; negative regulation of transcription, DNA-dependent; alveolus development; growth

Disease: Speech-language Disorder 1

Bailey, S.D., et al. Diabetes Care (2010) In press :
Tolosa, A., et al. BMC Med. Genet. 11, 114 (2010) :
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Stroud, J.C., et al. Structure 14(1):159-166(2006)
Gauthier, J., et al. Am. J. Med. Genet. A 118A (2), 172-175 (2003) :

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