FOXP2, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Goat

This item specifically recognises an epitope within the C-terminal (CT) region of human FOXP2, otherwise known as Forkhead box P2, a highly conserved member of the FOX family of transcription factors, which plays an essential role in brain and lung development.
Studies have revealed the importance of FOXP2 in mediating the development of speech and language, and mutations in the human FOXP2 gene have been linked to developmental verbal dyspraxia. This antibody is expected to recognise all three reported isoforms.

Purified
Purified IgG - liquid

IgG concentration 0.5mg/ml (lot specific)

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Small volumes of anti-FOXP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS223776 specifically recognises an epitope within the C-terminal (CT) region of human FOXP2, otherwise known as Forkhead box P2, a highly conserved member of the FOX family of transcription factors, which plays an essential role in brain and lung development. Studies have revealed the importance of FOXP2 in mediating the development of speech and language, and mutations in the human FOXP2 gene have been linked to developmental verbal dyspraxia. This antibody is expected to recognise all three reported isoforms.

ELISA (EIA), Western Blot (WB)

Western Blot: This item detects a band of approximately 80kDa in human cerebellum cell lysates.
ELISA: Minimum Dilution: 1/32000
Western Blotting: Minimum Dilution: 0.5; Maximum Dilution: 1.5ug/ml

Human cerebellum lysate probed with Goat anti human FOXP2 (MBS223776)

81,840 Da

forkhead box P2

forkhead box protein P2; CAG repeat protein 44; forkhead/winged-helix transcription factor; trinucleotide repeat containing 10; trinucleotide repeat-containing gene 10 protein

Forkhead box protein P2

CAGH44; TNRC10  [Similar Products]

FOXP2_HUMAN

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and ***** brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

FOXP2: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language. Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Isoform 1 and isoform 6 are expressed in ***** and fetal brain, caudate nucleus and lung. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: nucleus

Molecular Function: protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; metal ion binding; transcription factor activity

Biological Process: skeletal muscle development; caudate nucleus development; camera-type eye development; transcription, DNA-dependent; righting reflex; putamen development; negative regulation of transcription from RNA polymerase II promoter; vocal learning; post-embryonic development; smooth muscle development; positive regulation of mesenchymal cell proliferation; cerebellum development; cerebral cortex development; negative regulation of transcription, DNA-dependent; alveolus development; growth

Disease: Speech-language Disorder 1

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